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20-hydroxyeicosa-6(Z),15(Z)-dienoic acid

increases cerebral vascular tone both in vivo and in vitro

Also Known As:

20-HEDE; WIT002 cpd

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Arachidonic Acids: 122
        Hydroxyeicosatetraenoic Acids: 318
        20-hydroxyeicosa-6(Z),15(Z)-dienoic acid: 2
    - Essential Fatty Acids: 734
      - Arachidonic Acids: 122
        Hydroxyeicosatetraenoic Acids: 318
        20-hydroxyeicosa-6(Z),15(Z)-dienoic acid: 2

Experts

1.	Harder, David R: 1 article (03/2009)
2.	Kawashima, Naoya: 1 article (03/2009)
3.	Klaus, Judith A: 1 article (03/2009)
4.	Koehler, Raymond C: 1 article (03/2009)
5.	Miyata, Noriyuki: 1 article (03/2009)
6.	Omura, Tomohiro: 1 article (03/2009)
7.	Onishi, Michihito: 1 article (03/2009)
8.	Renic, Marija: 1 article (03/2009)
9.	Roman, Richard J: 1 article (03/2009)
10.	Campbell, William B: 1 article (02/2006)

Related Diseases

1.	Infarction (Infarctions) 02/01/2006 - "We further demonstrated that one 5-min period of ischemic preconditioning (IPC) reduced infarct size to a similar extent as that observed with the high doses of DDMS and 20-HEDE, and the higher dose of DDMS given simultaneously with IPC augmented the infarct size reduction [9.9 +/- 2.8% (IPC) to 2.5 +/- 1.4% (0.81 mg/kg DDMS), P < 0.05] to a greater degree than that observed with either treatment alone. " 03/01/2009 - "Administration of another 20-HETE inhibitor, HET0016 (0.01 to 1.0 mg/kg, iv) or a 20-HETE antagonist 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid (10 mg/kg, iv) also reduced infarct size. "
2.	Myocardial Infarction 02/01/2006 - "In addition, 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid (20-HEDE, a putative 20-HETE antagonist) significantly reduced myocardial infarct size from control [10.3 +/- 1.3% (0.032 mg/kg 20-HEDE) and 5.9 +/- 1.9% (0.064 mg/kg 20-HEDE), P < 0.05]. "

Related Drugs and Biologics

1.	Hydroxyeicosatetraenoic Acids (HETE)
2.	DDMS
3.	20-hydroxy-5,8,11,14-eicosatetraenoic acid
4.	HET0016