TRPV1 receptor

01/01/2015 - "Two TRPV1 receptor antagonists are effective in two different experimental models of migraine."
11/01/2012 - "However, experimental studies with TRPV1 receptor antagonists indicate that the receptor may not be a useful target for new acute migraine treatments. "
02/01/2011 - "Also our recent data have raised the possibility that the TRPV1 receptor may play a pivotal role for the chronification of migraine. "
01/01/2011 - "TRPV1 receptor blockade is ineffective in different in vivo models of migraine."
08/01/2009 - "First, we reviewed the pathophysiology of migraine and the function of the TRPV1 receptor at first. "

06/01/2012 - "The goal of this work was to determine the effects of TRPV1 receptor activation by potent agonists and/or colonic inflammation on voltage-gated Na(+) channels expressed in bladder sensory neurons. "
07/15/2011 - "Thus, the present results confirm and extend previous data supporting the involvement of C-fibers, but not the TRPV1 receptor, in allergic airway inflammation."
07/15/2011 - "Next we determined the effect of TRPV1 receptor blockade on allergic airway inflammation. "
09/01/2009 - "The activation of the TRPV1 receptor by its agonists reduces inflammation during I/R-induced injury through several pathways. "
01/01/2009 - "Parvalbumin and TRPV1 receptor expression in dorsal root ganglion neurons after acute peripheral inflammation."

12/01/2015 - "In this review, we summarize the main findings on the interactions between the cannabinoid, opioid and the TRPV1 receptor regarding to pain modulation. "
07/01/2013 - "Transient receptor potential vanilloid subtype 1 (TRPV1) receptor is a pain-sensing, ligand-gated, non-selective cation channel expressed in peripheral sensory neurons. "
02/14/2013 - "Modulation of TRPV1 Receptor for Treatment of Pain and Other Disorders."
01/01/2013 - "These effects are probably mediated via an activation of TRPV1 receptor - positive neurons in the nasal mucosa with subsequent central inhibitory effects (such as conditioned pain modulation). "
06/22/2012 - "However, the functional importance of glycosylation of the TRPV1 receptor, a key sensor of pain-sensing nerves, is not well understood, and whether TRPV1 is glycosylated in neurons is unclear. "

12/01/2009 - "Collectively, the results from these studies indicate that the AKAP150 scaffolding protein functionally modulates PKC-mediated phosphorylation and sensitization of the TRPV1 receptor in rat sensory neurons, suggesting the scaffolding protein to be an integral regulator of peripheral inflammatory hyperalgesia."
06/01/2014 - "TRPV1 receptor inhibition decreases CCL2-induced hyperalgesia."
01/01/2014 - "The analgesic effect of the TRPV1 receptor antagonist was especially evident in the reduction of thermal hyperalgesia. "
09/01/2013 - "Together these data indicate that swim stress-induced musculoskeletal hyperalgesia is mediated, in part, by CRF2 receptors but is independent of the TRPV1 receptor."
01/01/2013 - "Contribution of TRPV1 receptor-expressing fibers to spinal ventral root after-discharges and mechanical hyperalgesia in a spared nerve injury (SNI) rat model."

07/01/2005 - "The present study investigated the role of this receptor in chronic arthritis evoked by complete Freund's adjuvant (CFA) using TRPV1 receptor gene-deleted (TRPV1-/-) mice and wild-type counterparts (TRPV1+/+). "
05/06/2004 - "The present study investigated whether the proportion of neurones with TRPV1 receptor increases in lumbar DRG neurones in the course of an antigen-induced arthritis (AIA) of one knee joint in the rat. "
11/01/2007 - "Transient potential vanilloid 1 (TRPV1) receptor is an ion channel receptor primarily localized on sensory nerves and activated by specific stimuli to initiate and amplify pain and inflammation, as typified by murine models of scald and arthritis. "