perchlorate

03/01/1998 - "Perchlorate has a fast turnover in the body and requires frequent daily doses for therapy of thyrotoxicosis. "
06/15/1961 - "The nephrotic syndrome as a complication of perchlorate treatment of thyrotoxicosis."
04/01/1990 - "Perchlorate and corticoids may be useful in the treatment of thyrotoxicosis."
03/01/1962 - "Combined treatment of thyrotoxicosis with perchlorate and propylthiouracil."
05/01/1999 - "The use of perchlorate for the prevention of thyrotoxicosis in patients given iodine rich contrast agents."

06/01/1983 - "Hypothyroidism associated with positive results of the perchlorate discharge test in elderly patients."
11/01/2008 - "Our study shows that maternal perchlorate exposure led to embryonic hypothyroidism and may have interfered with embryonic development."
07/01/2022 - "Disruption of SLC5A5 function by perchlorate, a pervasive environmental contaminant, leads to human pathologies, especially hypothyroidism. "
08/01/2011 - "Thirty unrelated children with CH or subclinical hypothyroidism (SH) identified during infancy with a eutopic thyroid gland, coming from our Screening Centre for CH or referred from other regions of Italy, were studied with the perchlorate discharge test to identify organification defects. "
10/01/2009 - "We concluded that perchlorate exposure caused hypothyroidism in young Japanese quail and affected the expression of thyroid-responsive genes during early posthatch development."

02/16/2016 - "Prophylactic drugs could be considered in high-risk populations, such as administration of perchlorate and a thionamide class drug to elderly patients with suppressed TSH and/or palpable goiter, started the day before and continued for two weeks after ICM administration."
01/01/2011 - "The perchlorate discharge test can detect the underlying thyroid biochemical defect and is useful for the evaluation of goiter or for the clinical diagnosis of PDS in a patient with a non-diagnostic SLC26A4 genotype. "
06/30/2010 - "This dyshormonogenesis displays a wide phenotype variation and is characterized usually by: the presence of congenital goiter or goiter appearing shortly after birth, high (131)I uptake, negative perchlorate discharge test, low serum TG and elevated serum TSH with simultaneous low serum T(4) and low, normal or high serum T(3). "
03/01/2010 - "Although 15dPGJ2 has no effect in perchlorate-goiters, the reduction of OS by NAC is associated with altered goiter development, making OS a required condition for the growth of the thyroid gland."
03/01/2010 - "In perchlorate-goiters, TSH plasma levels remained elevated and Tg-I-negative after NAC or 15dPGJ2 treatment. "

07/01/1997 - "The perchlorate discharge test, the gold-standard investigation for Pendred syndrome, is non-specific, and in the absence of alternative means of confirming the diagnosis, its sensitivity is unknown. "
10/01/2019 - "Therefore, to determine whether the variant was specifically associated with Pendred Syndrome (PDS) or DFNB4, biochemical analyses, PTA, thyroid scans by Tc99m, perchlorate discharge test and high-resolution CT scan of the temporal bone were carried out on the affected family members. "
01/01/2013 - "A possible association with Pendred syndrome needs to be confirmed by genetic investigations with search for mutations in the SLC26A4 gene and further clinical tests, such as Perchlorate test for surveillance of thyroid function."
07/01/2005 - "The clinical diagnosis of Pendred's syndrome was supported by a positive perchlorate discharge test in the three afflicted siblings. "
10/01/2002 - "Perchlorate discharge tests were positive in both infants leading to a diagnosis of Pendred syndrome. "

07/01/2001 - "Increased incidence of thyroid follicular hypertrophy was observed in does treated with > or =10 mg/kg-day perchlorate and significantly decreased T4 was observed in does treated with > or =30 mg/kg-day. "
08/01/2012 - "The results indicated that high dose perchlorate (520 mg kg(-1) b.wt.) can induce a significant decrease in body weight and cause hypertrophy of thyroid gland, with a decreased level of FT3, FT4 and a remarkable increased level of TSH. "
07/15/2005 - "Follicular epithelial cell height, hyperplasia, and hypertrophy increased with increasing perchlorate concentration, especially in fish exposed for 30 d, and these effects were statistically significantly different from control at concentrations as low as 0.1 mg/L (nominal concentration). "
02/01/2006 - "There was no evidence of colloid depletion or hyperplasia in frogs from any of the sites, although frogs from two sites with greatest mean water perchlorate concentrations exhibited significantly greater follicle cell hypertrophy. "
04/01/2013 - "Thyrocyte hypertrophy, an index of hypothyroidism, was observed at 45 and 60 dpf in perchlorate-treated but only at 45 dpf in methimazole-treated fish. "