MP4 maleimide-polyethylene glycol-modified hemoglobin

4% MalPEG-Hb in lactated Ringer; used as a hemoglobin-based oxygen carrier

Also Known As:

maleimide-polyethylene glycol-modified hemoglobin, MP4; Hemospan; Hemospan PS; MP4 (MalPEG-Hb); MP4OX cpd; MalPEG-Hb, MP4

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - MP4 maleimide-polyethylene glycol-modified hemoglobin: 5
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        MP4 maleimide-polyethylene glycol-modified hemoglobin: 5
Organic Chemicals: 133
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - Maleimides: 16
        MP4 maleimide-polyethylene glycol-modified hemoglobin: 5
Macromolecular Substances: 97
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - MP4 maleimide-polyethylene glycol-modified hemoglobin: 5
Biomedical and Dental Materials
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - MP4 maleimide-polyethylene glycol-modified hemoglobin: 5
Technology, Industry, and Agriculture
- Manufactured Materials
  - Biomedical and Dental Materials
    - Polymers: 13051
      - Polyethylene Glycols: 3865
        MP4 maleimide-polyethylene glycol-modified hemoglobin: 5

Experts

1.	Acharya, Seetharama A: 1 article (12/2019)
2.	Bhutoria, Savita: 1 article (12/2019)
3.	Branch, Craig: 1 article (12/2019)
4.	Gerfen, Gary: 1 article (12/2019)
5.	Intaglietta, Marcos: 1 article (12/2019)
6.	Kaul, Dhananjaya: 1 article (12/2019)
7.	Meng, Fantao: 1 article (12/2019)
8.	Thangaswamy, Sangeetha: 1 article (12/2019)
9.	Cameron, Scott J: 1 article (02/2009)
10.	Engelstad, Michael: 1 article (02/2009)

Related Diseases

1.	Wounds and Injuries (Trauma) 08/01/2007 - "Polyheme is a polymerized human hemoglobin in early phase III clinical trials with trauma patients, having infused up to 10,000 ml, with efficacy apparently demonstrated in phase II. The Sangart product, Hemospan, is currently undergoing phase II trials. "
2.	Chronic Limb-Threatening Ischemia 09/01/2008 - "Hemospan is currently undergoing phase III clinical trials in Europe and phase II clinical trials in the US for use as a blood substitute, and phase II clinical trials in Sweden for critical limb ischemia." 09/01/2008 - "Hemospan, a novel hemoglobin-based oxygen carrier and plasma expander, is being developed by Sangart Inc for use as a blood substitute and for the treatment of critical limb ischemia. " 09/01/2008 - "Hemospan: a hemoglobin-based oxygen carrier for potential use as a blood substitute and for the potential treatment of critical limb ischemia."
3.	Hypotension (Low Blood Pressure) 12/01/2006 - "In comparison with Ringer's acetate, Hemospan mildly elevates hepatic enzymes and lipase and is associated with less hypotension and more bradycardic events. "
4.	Hemolysis 02/01/2009 - "Interfering Hemospan concentrations were determined for general chemistry and cardiac marker analytes in pooled serum and the corresponding hemolysis index was calculated. "
5.	Sickle Cell Anemia (Hemoglobin S Disease) 12/01/2019 - "Abbreviations: 2-IT: 2-immothiolane; Mal-T: 4-Maleimido tempo; Alb: human serum albumin (HSA); Alb-T12: human albumin conjugated with 12 copies of tempo; EAF: extension arm facilitated; EAF PEG Hb: extension arm facilitated PEGylated haemoglobin; EAF PEG Alb: extension arm facilitated PEGylated albumin; EAF P3K6 Hb: extension arm facilitated PEGylated haemoglobin conjugated with 6 copies of PEG3K; EAF P5K6 Alb T12: extension arm facilitated PEGylated albumin conjugated with 6 copies of PEG5K and 12 copies of tempo; Hb: haemoglobin; HAS: human serum albumin (Alb); PEG: polyethylene glycol; MP4: MalPEG Hb, is formulated at 4.2 g/dL in lactated Ringer's solution, a product of Sangart; SCD: sickle cell disease; NO: nitric oxide; SEC: size exclusive chromatography; Vrbc: red cell velocity; Q: volumetric flow rates, Q; SNP: sodium nitroprusside."

Related Drugs and Biologics

1.	Hemoglobins (Hemoglobin)
2.	Blood Substitutes (Artificial Blood)
3.	PolyHeme
4.	Polyethylene Glycols (Polyethylene Glycol)
5.	Oxygen (Dioxygen)
6.	Nitroprusside (Sodium Nitroprusside)
7.	Nitric Oxide (Nitrogen Monoxide)
8.	Lipase (Acid Lipase)
9.	Enzymes
10.	Albumins