heteronemin

12/06/2018 - "In the current study, we investigate the antitumor mechanism of heteronemin in cholangiocarcinoma cells and further explore its molecular targets. "
12/06/2018 - "Initially, heteronemin exhibited potent cytotoxic effects against cholangiocarcinoma HuccT1 and SSP-25 cells. "
12/06/2018 - "Heteronemin Induces Anti-Proliferation in Cholangiocarcinoma Cells via Inhibiting TGF-β Pathway."
01/01/2021 - "Heteronemin is a marine natural product isolated from Hippospongia sp. that has been found to protect against carcinogenesis in cholangiocarcinoma, prostate cancer, and acute myeloid leukemia. "
12/06/2018 - "The results indicate that heteronemin was able to modulate cell adhesion, the expression of extracellular matrix (ECM) receptors, the TGF-β pathway, cell motility, the membrane integration, metastasis response, matrix metalloproteinase (MMP) remodeling, the regulation of metabolism, sprouting angiogenesis, transcription factors, and vasculogenesis in cholangiocarcinoma cell lines. "

02/15/2010 - "In this study, we investigated the biological effects of heteronemin, a marine sesterterpene isolated from the sponge Hyrtios sp. on chronic myelogenous leukemia cells. "

09/29/2023 - "This study underscores the potential of heteronemin as a ferroptosis inducer in pancreatic cancer cells. "
09/29/2023 - "This study delves into the potential of heteronemin as a ferroptotic agent against pancreatic cancer, using the Panc-1 cell line as a model. "
09/29/2023 - "Heteronemin promotes iron-dependent cell death in pancreatic cancer."

01/01/2019 - "This study mainly investigated the effects of BA6 (heteronemin), the marine sponge sesterterpene, on lung cancer cell apoptosis, via modulation of mitochondrial reactive oxygen species (mtROS) and oxidative phosphorylation (OXPHOS). "

07/27/2022 - "Heteronemin or the combined treatment suppressed PD-L1 expression in both cancer cell lines. "
07/27/2022 - "Heteronemin or combined treatment downregulated genes associated with cancer progression and decreased cell motility. "
07/27/2022 - "A secondary metabolite in the sponge Hippospongia sp., Heteronemin, has been shown to induce anti-proliferation in several types of cancers. "
06/15/2022 - "The power of heteronemin in cancers."
03/01/2022 - "On the other hand, the most abundant secondary metabolite in the sponge Hippospongia sp., heteronemin, shows effective cytotoxic activity against different types of cancer cells. "