GUT-70

tricyclic coumarin from the stem bark of Calophyllum brasiliense collected in Brazil, significantly inhibits the growth of leukemic cells; structure in first source

Also Known As:

5-methoxy-2,2-dimethyl-6-(2-methyl-1-oxo-2-butenyl) -10-propyl-2H,8H-benzo(1,2-b;3,4-b')dipyran-8-one

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        GUT-70: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        GUT-70: 6

Experts

1.	Kimura, Shinya: 5 articles (02/2015 - 01/2005)
2.	Goto, Hiroki: 2 articles (02/2015 - 02/2013)
3.	Hattori, Shinichiro: 2 articles (02/2015 - 02/2013)
4.	Kariya, Ryusho: 2 articles (02/2015 - 02/2013)
5.	Kudo, Eriko: 2 articles (02/2015 - 02/2013)
6.	Matsuda, Kouki: 2 articles (02/2015 - 02/2013)
7.	Okada, Seiji: 2 articles (02/2015 - 02/2013)
8.	Taura, Manabu: 2 articles (02/2015 - 02/2013)
9.	Maekawa, Taira: 2 articles (06/2011 - 01/2005)
10.	Komizu, Yuji: 1 article (02/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2005 - "Thus, a novel anti-cancer drug, GUT-70 isolated from the stem bark of C. " 01/01/2005 - "During our search for cancer chemopreventing compounds derived from plant sources, we discovered that the natural product GUT-70, isolated from the stem bark of Calophyllum brasiliense collected in Brazil, significantly inhibits the growth of leukemic cells. " 07/01/2014 - "These findings indicated that GUT-70 could serve as a lead compound to develop novel therapeutic agents against cancer and HIV-1 infection." 07/01/2014 - "Furthermore, we synthesized BNS-22 as a derivative of GUT-70, which showed more antiproliferative activity against human cancer cells than GUT-70. " 07/01/2014 - "During our search for cancer chemopreventing compounds derived from plant sources, we discovered that the natural product GUT-70, isolated from the stem bark of Calophyllum Brasiliense collected in Brazil, significantly inhibited the growth of leukemic cells via the induction of caspase-mediated and p53-independent apoptosis. "
2.	Infections 02/13/2015 - "Thus, these unique properties of GUT-70 enable the development of novel therapeutic agents against HIV-1 infection. " 02/01/2013 - "Our results strengthen the idea that NF-κB pathway is one of the potential targets to control HIV-1 replication and that GUT-70 could serve as a lead compound to develop novel therapeutic agents against HIV-1 infection." 07/01/2014 - "These findings indicated that GUT-70 could serve as a lead compound to develop novel therapeutic agents against cancer and HIV-1 infection."
3.	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 01/04/2011 - "Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma." 01/04/2011 - "Mantle cell lymphoma cell lines with known p53 status were treated with GUT-70, a tricyclic coumarin derived from Calophyllum brasiliense, and the biological and biochemical consequences of GUT-70 were studied. "

Related Drugs and Biologics

1.	BNS 22
2.	Caspases
3.	coumarin