tenuigenin

decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells

Also Known As:

12-(Chloromethyl)-2b,3b-dihydroxy-27; senegenin; 4,8a(1H)-Picenedicarboxylic acid, 13-(chloromethyl)-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydro-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-, (2S,3R,4S,4aR,6aR,8aS,12aS,13S,14aR,14bR)-

Networked: 35 relevant articles (8 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zheng, Yan: 4 articles (12/2017 - 07/2012)
2.	Wang, Xiaomin: 3 articles (12/2017 - 06/2011)
3.	Wang, Yong: 3 articles (09/2013 - 06/2011)
4.	Liang, Zhigang: 2 articles (12/2017 - 06/2011)
5.	Lu, Li: 2 articles (01/2017 - 06/2011)
6.	Ci, Xinxin: 2 articles (01/2016 - 09/2015)
7.	Lu, Gejin: 2 articles (01/2016 - 09/2015)
8.	Lv, Hongming: 2 articles (01/2016 - 09/2015)
9.	Zheng, Yuwei: 2 articles (01/2016 - 09/2015)
10.	He, Yi: 2 articles (09/2013 - 07/2012)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 06/22/2011 - "Tenuigenin, an active component of Polygala tenuifolia root extracts, has been shown to provide antioxidative and anti-aging effects in Alzheimer's disease, as well as to promote proliferation and differentiation of neural progenitor cells. " 08/26/2004 - "Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells." 01/01/2018 - "Combined application of tenuigenin and β-asarone improved the efficacy of memantine in treating moderate-to-severe Alzheimer's disease." 01/01/2018 - "Efficacy of tenuigenin and β-asarone as augmentations for memantine in the treatment of Alzheimer's disease." 01/01/2021 - "It was noted, that the capacities of the tenuigenin to decrease the secretion of beta amyloid and to protect of neurons from damage by already made beta ameloids, to inhibit the processes of the tau proteins` hyperphosphorylation and inflammations in microglia, as well as increase the main synaptic transmission can be used by the development of effective therapeutic drugs aimed to reduce the pathogenesis of Alzheimer`s disease. "
2.	Acute Kidney Injury (Acute Renal Failure) 12/05/2016 - "Corrigendum to "Tenuigenin exhibits protective effects against LPS-induced acute kidney injury via inhibiting TLR4/NF-κB signaling pathway" [Eur. " 11/15/2016 - "Tenuigenin exhibits protective effects against LPS-induced acute kidney injury via inhibiting TLR4/NF-κB signaling pathway." 11/01/2017 - "Protective role of tenuigenin on sepsis-induced acute kidney injury in mice."
3.	Cognitive Dysfunction 04/01/2014 - "However, the mechanism underlying the effects of senegenin against postoperative cognitive impairment in elderly individuals has yet to be elucidated. " 01/01/2012 - "Furthermore, we found that administration of senegenin by gavage attenuated HIR-induced cognitive impairment in a dose and time dependent manner, and its mechanisms might partly due to the increasing expression of NR2B in rat hippocampus. " 04/01/2014 - "Results from a Morris water maze test suggested that splenectomy induced a transient cognitive deficiency in the elderly rats; however, when the rats were treated with senegenin, the cognitive impairment was notably attenuated. " 01/01/2012 - "In this study, we investigated the protective effects of senegenin, an component of Polygala tenuifolia root extracts, on cognitive dysfunction induced by hepatic ischemia-reperfusion. " 01/01/2012 - "Senegenin attenuates hepatic ischemia-reperfusion induced cognitive dysfunction by increasing hippocampal NR2B expression in rats."
4.	Acute Lung Injury 09/15/2015 - "Tenuigenin ameliorates acute lung injury by inhibiting NF-κB and MAPK signalling pathways." 04/01/2016 - "The purpose of this study was to assess the protective effect of senegenin on acute lung injury (ALI) in rats induced by sepsis. " 09/15/2015 - "We aimed to explore the protective effect of tenuigenin (TNG) on lipopolysaccharide (LPS)-stimulated inflammatory responses in acute lung injury (ALI). " 04/01/2016 - "Senegenin Ameliorate Acute Lung Injury Through Reduction of Oxidative Stress and Inhibition of Inflammation in Cecal Ligation and Puncture-Induced Sepsis Rats."
5.	Postmenopausal Osteoporosis 01/01/2017 - "Recent studies have suggested that Tenuigenin (TEN), a class of native compounds with numerous biological activities such as anti-resorptive properties, exerts protective effects against postmenopausal bone loss. "

Related Drugs and Biologics

1.	Memantine (Namenda)
2.	asarone
3.	Neuroprotective Agents
4.	Proteins (Proteins, Gene)
5.	Synucleins
6.	tau Proteins (tau Protein)
7.	Amyloid beta-Peptides
8.	Lipopolysaccharides
9.	Amyloid (Amyloid Fibrils)
10.	tenuifolin diterpene

Related Therapies and Procedures

1.	Therapeutics
2.	Splenectomy
3.	Punctures
4.	Ligation
5.	Oral Administration