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versipelostatin

inhibits the unfolded protein response; possible antineoplastic agent

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Oligosaccharides: 3566
    - versipelostatin: 2
Organic Chemicals: 133
- Lactones: 1549
  - Macrolides: 4391
    - versipelostatin: 2
  - Polyketides: 231
    - Macrolides: 4391
      - versipelostatin: 2
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Polyketides: 231
    - Macrolides: 4391
      - versipelostatin: 2

Experts

1.	Saito, Sakae: 1 article (01/2011)
2.	Tomida, Akihiro: 1 article (01/2011)
3.	Shin-Ya, Kazuo: 1 article (05/2005)

Related Diseases

1.

Neoplasms (Cancer)

01/01/2011 - "By microarray analysis, we demonstrated that cancer cells under glucose deprivation conditions caused activation of the UPR transcription program, which was suppressed broadly by versipelostatin and biguanides. "
05/01/2005 - "Versipelostatin decreased the expression of GRP78 accompanied by a high level of cell death under glucose deprived conditions that mimicked the circumstances of a solid tumor. "
01/01/2011 - "Versipelostatin and biguanides show highly selective cytotoxicity to glucose-deprived tumor cells and exert in vivo antitumor activity; thus, these compounds would be interesting anticancer agent candidates. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Biguanides
3.	Antineoplastic Agents (Antineoplastics)
4.	Endoplasmic Reticulum Chaperone BiP