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5,7,3',4',5'-pentamethoxyflavone

antineoplastic agent that reverses P-glycoprotein-mediated multidrug resistance; structure in first source

Also Known As:

3',4',5',5,7-pentamethoxyflavone

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        5,7,3',4',5'-pentamethoxyflavone: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        5,7,3',4',5'-pentamethoxyflavone: 4

Experts

1.	Brown, Karen: 4 articles (02/2011 - 04/2009)
2.	Gescher, Andreas J: 4 articles (02/2011 - 04/2009)
3.	Steward, William P: 4 articles (02/2011 - 04/2009)
4.	Cai, Hong: 3 articles (02/2011 - 04/2009)
5.	Sale, Stewart: 3 articles (02/2011 - 08/2009)
6.	Britton, Robert G: 2 articles (02/2011 - 08/2009)
7.	Fong, Isabel L: 1 article (11/2009)
8.	Landuzzi, Lorena: 1 article (11/2009)
9.	de Giovanni, Carla: 1 article (11/2009)
10.	Schmid, Ralf: 1 article (08/2009)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 02/01/2011 - "The flavones tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone) and 3',4',5',5,7-pentamethoxyflavone (PMF) are under development as potential colorectal cancer chemopreventive agents as they reduced adenoma development in the Apc(Min) mouse model of intestinal carcinogenesis. " 08/01/2009 - "Here, three related flavones, apigenin (4',5,7-trihydroxyflavone), tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), and 3',4',5',5,7-pentamethoxyflavone (PMF), were compared in terms of their effects on (a) adenoma development in Apc(Min) mice, a model of human gastrointestinal malignancies; (b) growth of APC10.1 mouse adenoma cells in vitro; and (c) prostaglandin E-2 generation in HCA-7 human-derived colorectal cancer cells in vitro. " 11/01/2009 - "The growth inhibitory properties of 14 putative colorectal cancer chemopreventive agents, tricin, apigenin, 3',4',5',5,7-pentamethoxyflavone, resveratrol, curcumin, 3,4-methylenedioxy-3',4',5'-trimethoxychalcone (DMU135), 3,4,5,4'-tetramethoxystilbene (DMU212), celecoxib, aspirin, piroxicam, all-trans-retinoic acid, difluoromethylornithine (DFMO), quercetin and cyanidin-3-glucoside, were studied in this cell line, and the IC(50) values were calculated. "
2.	Adenoma (Adenomas) 04/01/2009 - "In a preliminary experiment 3',4',5',5,7-pentamethoxyflavone (PMF) inhibited adenoma development in Apc(Min) mice, a model of the human heritable condition familial adenomatous polyposis. " 02/01/2011 - "The flavones tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone) and 3',4',5',5,7-pentamethoxyflavone (PMF) are under development as potential colorectal cancer chemopreventive agents as they reduced adenoma development in the Apc(Min) mouse model of intestinal carcinogenesis. " 08/01/2009 - "Here, three related flavones, apigenin (4',5,7-trihydroxyflavone), tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), and 3',4',5',5,7-pentamethoxyflavone (PMF), were compared in terms of their effects on (a) adenoma development in Apc(Min) mice, a model of human gastrointestinal malignancies; (b) growth of APC10.1 mouse adenoma cells in vitro; and (c) prostaglandin E-2 generation in HCA-7 human-derived colorectal cancer cells in vitro. "
3.	Neoplasms (Cancer) 02/01/2011 - "Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone)." 08/01/2009 - "Here, three related flavones, apigenin (4',5,7-trihydroxyflavone), tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone), and 3',4',5',5,7-pentamethoxyflavone (PMF), were compared in terms of their effects on (a) adenoma development in Apc(Min) mice, a model of human gastrointestinal malignancies; (b) growth of APC10.1 mouse adenoma cells in vitro; and (c) prostaglandin E-2 generation in HCA-7 human-derived colorectal cancer cells in vitro. "
4.	Carcinogenesis 02/01/2011 - "The flavones tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone) and 3',4',5',5,7-pentamethoxyflavone (PMF) are under development as potential colorectal cancer chemopreventive agents as they reduced adenoma development in the Apc(Min) mouse model of intestinal carcinogenesis. "
5.	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 04/01/2009 - "In a preliminary experiment 3',4',5',5,7-pentamethoxyflavone (PMF) inhibited adenoma development in Apc(Min) mice, a model of the human heritable condition familial adenomatous polyposis. "

Related Drugs and Biologics

1.	tricin
2.	Apigenin
3.	Flavones
4.	Tretinoin (Retinoic Acid)
5.	Quercetin
6.	Prostaglandins
7.	Piroxicam (Feldene)
8.	Curcumin
9.	Aspirin (Acetylsalicylic Acid)
10.	Eflornithine (Ornidyl)