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cortagine

chimeric peptide, [Glu(21),Ala(40)][sauvagine(1-12)]x[human/rat corticotropin-releasing factor(14-30)]x[sauvagine(30-40)]

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Larauche, Muriel: 2 articles (01/2015 - 07/2009)
2.	Million, Mulugeta: 2 articles (01/2015 - 07/2009)
3.	Rivier, Jean: 2 articles (01/2015 - 07/2009)
4.	Taché, Yvette: 2 articles (01/2015 - 07/2009)
5.	Biraud, Mandy: 1 article (01/2015)
6.	Mulak, Agata: 1 article (01/2015)
7.	Adelson, David W: 1 article (07/2009)
8.	Brunnhuber, Stefan: 1 article (07/2009)
9.	Gourcerol, Guillaume: 1 article (07/2009)
10.	Pambukchian, Karina: 1 article (07/2009)

Related Diseases

1.	Hypersensitivity (Allergy) 01/01/2015 - "The sst1 agonist (3 and 10μg) prevented cortagine-induced hypersensitivity to CRD at each pressure while the sst2 agonist at 10μg reduced it. " 07/01/2009 - "Intraperitoneal (ip) cortagine also increased colonic permeability, activated proximal and distal colonic myenteric neurons, and induced visceral hypersensitivity to a second set of phasic colorectal distention (CRD). " 07/01/2009 - "Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways." 01/01/2015 - "We investigated the influence of the stable sst1-5 agonist, ODT8-SST and selective receptor subtype peptide agonists (3 or 10μg/mouse) injected intraperitoneally (ip) on visceral hypersensitivity in mice induced by repeated noxious colorectal distensions (four sets of three CRD, each at 55mmHg) or corticotropin-releasing factor receptor 1 agonist, cortagine given between two sets of graded CRD (15, 30, 45, and 60mmHg, three times each pressure). "
2.	Hyperalgesia 07/01/2009 - "The CRF antagonist astressin (10 mug/kg ip) abolished ip cortagine-induced hyperalgesia whereas injected icv it had no effect. "
3.	Diarrhea 07/01/2009 - "In mice, cortagine (30 microg/kg ip) stimulated defecation by 7.8-fold, induced 60% incidence of diarrhea, and increased VMR to CRD. " 07/01/2009 - "Compared with vehicle, cortagine (10 microg/kg ip) significantly decreased the distal colonic transit time by 45% without affecting gastric transit, increased distal and transverse colonic contractility by 35.6 and 66.2%, respectively, and induced a 7.1-fold increase in defecation and watery diarrhea in 50% of rats during the first hour postinjection whereas intracerebroventricular (icv) cortagine (3 microg/rat) had lesser effects. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	astressin
3.	CRF receptor type 1