MAE 87

an oxoindolinone; local injection of receptor tyrosine kinase inhibitor MAE 87 reduces retinal neovascularization in mice; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Agostini, Hansjürgen T: 1 article (07/2004)
2.	Giannis, Athanassios: 1 article (07/2004)
3.	Hansen, Lutz L: 1 article (07/2004)
4.	Junker, Bernd: 1 article (07/2004)
5.	Martin, Gottfried: 1 article (07/2004)
6.	Mazitschek, Ralph: 1 article (07/2004)
7.	Unsoeld, Anke S: 1 article (07/2004)

Related Diseases

1.	Retinal Neovascularization 07/15/2004 - "After a single intravitreal injection of MAE 87 there were significantly less angioproliferative changes (blood vessel tufts, extra-retinal neovascularization, and blood vessel tortuosity) than in the fellow eye (p=0.007). " 07/15/2004 - "The tyrosine kinase inhibitor MAE 87 may be a promising substance for local treatment of retinal neovascularization. " 07/15/2004 - "Local injection of receptor tyrosine kinase inhibitor MAE 87 reduces retinal neovascularization in mice."
2.	Diabetic Retinopathy (Retinopathy, Diabetic) 07/15/2004 - "Due to its ability to inhibit not only the VEGF but also the IGF-1 cascade, MAE 87 may prove especially valuable for the treatment of diabetic retinopathy."

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
3.	Insulin-Like Growth Factor I (IGF-1)
4.	Tyrosine Kinase Inhibitors

Related Therapies and Procedures

1.	Intravitreal Injections