GFA 116

consists of a calix(4)arene scaffold attached to four cyclic GKGK peptides; inhibits tumorigenesis and angiogenesis in mice; inhibits VEGF binding to Flk-1; structure in first source

Also Known As:

GFA-116; GFA116

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        GFA 116: 1
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - GFA 116: 1
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - GFA 116: 1
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - GFA 116: 1

Experts

1.	Blaskovich, Michelle A: 1 article (05/2004)
2.	Brem, Steven: 1 article (05/2004)
3.	Choi, Kihang: 1 article (05/2004)
4.	Coppola, Domenico: 1 article (05/2004)
5.	Delarue, Frederic: 1 article (05/2004)
6.	Hamilton, Andrew D: 1 article (05/2004)
7.	Jain, Rishi K: 1 article (05/2004)
8.	Lin, Qing: 1 article (05/2004)
9.	Mullan, Michael: 1 article (05/2004)
10.	Paris, Daniel: 1 article (05/2004)

Related Diseases

1.	Carcinogenesis 05/15/2004 - "Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor."
2.	Neoplasms (Cancer) 05/15/2004 - "In vivo, GFA-116 (50 mpk/day) inhibits tumor growth and angiogenesis as measured by CD31 staining of A-549 human lung tumors in nude mice. " 05/15/2004 - "Furthermore, GFA-116 is also effective at inhibiting tumor growth and metastasis to the lung of B16-F10 melanoma cells injected into immunocompetent mice. " 05/15/2004 - "From this library, we discovered GFA-116, which potently inhibits (125)I-VEGF binding to Flk-1 in Flk-1-overexpressing NIH 3T3 cells and human prostate tumor cells with an IC(50) of 750 nM. This inhibition is highly selective for VEGF in that (125)I- platelet-derived growth factor binding to its receptor is not affected. "
3.	Neoplasm Metastasis (Metastasis) 05/15/2004 - "Furthermore, GFA-116 is also effective at inhibiting tumor growth and metastasis to the lung of B16-F10 melanoma cells injected into immunocompetent mice. "
4.	Melanoma (Melanoma, Malignant) 05/15/2004 - "Furthermore, GFA-116 is also effective at inhibiting tumor growth and metastasis to the lung of B16-F10 melanoma cells injected into immunocompetent mice. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Platelet-Derived Growth Factor