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NSC 23766

a Rac GTPase inhibitor; structure in first source

Also Known As:

NSC-23766; NSC23766

Networked: 80 relevant articles (8 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - NSC 23766: 80
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Aminoquinolines: 29
        NSC 23766: 80

Experts

1.	Zheng, Yi: 5 articles (03/2006 - 05/2004)
2.	Tan, Andrew M: 4 articles (01/2017 - 12/2008)
3.	Waxman, Stephen G: 4 articles (01/2017 - 12/2008)
4.	Liu, Huanhuan: 3 articles (07/2019 - 10/2014)
5.	Zhu, Shouan: 3 articles (07/2019 - 10/2014)
6.	Thorlacius, Henrik: 3 articles (10/2017 - 01/2013)
7.	Wu, Yan: 3 articles (01/2016 - 10/2014)
8.	Zhao, Peng: 3 articles (10/2013 - 12/2008)
9.	Zheng, Jie: 3 articles (01/2006 - 05/2004)
10.	Xia, Limin: 2 articles (01/2022 - 01/2020)

Related Diseases

1.	Infections 01/01/2014 - "The antiviral potential of NSC23766 was confirmed in mouse experiments, identifying Rac1 as a new cellular target for therapeutic treatment of influenza virus infections. " 11/30/2014 - "Infection of cells by adenoviruses expressing dominant negative Rac1 (Rac1-N17), Cdc42 (Cdc42-N17) or constitutively active RhoA (RhoA-V14), or incubation of cells with pharmacological inhibitors of Rac1 (NSC23766) or Cdc42 (ML141) significantly protected neuroblastoma cells from metformin-induced apoptosis. " 01/01/2020 - "Double-stranded RNA replication intermediate was generated between 2 and 3 h postinfection (p.i.), and viral capsid production was initiated between 4 and 5 h p.i. The drugs affecting Rac1 (NSC 23766) and cholesterol (filipin III) compromised infection, whereas bafilomycin A1, dyngo, U-73122, wortmannin, and nocodazole did not, suggesting the virus follows an enterovirus-triggered macropinocytic pathway rather than the clathrin pathway. "
2.	Infarction (Infarctions) 01/01/2018 - "Intracerebroventricular administration of lentivirus expressing the Rac1 small hairpin RNA (shRNA) and specific Rac1 inhibitor NSC23766 not only decreased the infarct volumes and improved neurologic deficits with a correlated significant activation of mitochondrial DNA specific proteins, such as OGG1 and POLG, but also elevated Bcl-2 S70 phosphorylation in mitochondria. " 10/15/2015 - "In this in vivo model of cerebral IR injury, mice treated with the Rac GTPase inhibitor NSC23766 or Rac1 small interfering RNA (siRNA) had better short-term (72 h) neurologic scores, less infarction volume, higher production of antioxidant enzymes, lower lipid peroxide, and reduced apoptosis compared with a vehicle-treated group or a control-siRNA group. "
3.	Vascular Remodeling 01/01/2017 - "However, treatment with NSC23766 significantly decreased inflammasome activation and macrophage infiltration, improved alveolar and vascular development, and reduced pulmonary vascular remodeling and RVH. "
4.	Cardiotoxicity 01/01/2018 - "These molecular markers of cardiotoxicity were mitigated to a similar extent by co-treatment with either lovastatin (10 mg/kg BW, p.o.) or NSC23766 (5 mg/kg BW, i.p.) three times a week. " 01/01/2018 - "Here we investigated whether specific inhibition of Rac1 by NSC23766 is as effective as lovastatin in preventing subacute cardiotoxicity following doxorubicin treatment. "
5.	Reperfusion Injury 10/01/2014 - "Thus, our data indicate that NSC23766 has therapeutic potential against cerebral ischemic reperfusion injury and that NSC23766 significantly ameliorates neuronal apoptosis by suppressing mitochondrial p53 translocation in streptozotocin-induced diabetic rats. "

Related Drugs and Biologics

1.	Inflammasomes
2.	Small Interfering RNA (siRNA)
3.	Proteins (Proteins, Gene)
4.	Chitosan
5.	Lovastatin (Mevacor)
6.	Streptozocin (Streptozotocin)
7.	Pilocarpine (Ocusert)
8.	Lithium
9.	Enzyme Inhibitors (Inhibitors, Enzyme)
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Vascular Surgical Procedures
3.	Intraperitoneal Injections
4.	Therapeutics
5.	Punctures