N- pip- phenylalanine- homophenylalanine- vinyl sulfone phenyl

a specific cysteine protease inhibitor

Also Known As:

4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S)-1-phenyl-5- (phenylsulfonyl)pentan-3-yl)amino)propan-2-yl)piperazine-1-carboxamide; 4-methylpiperazine-1-carboxylic acid(1-((3-benzenesufonyl-1-phenethylallyl)carbamoyl)-2-phenylethyl)amide; APC 3316; APC-3316; APC3316; CRA 3316; CRA-3316; CRA3316; K-1177; K-11777; K-777 cpd; K1177; K11777; K777 cpd; N-Pip-F-hF-VS Phenyl; SLV-213; SLV213

Networked: 7 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	McKerrow, James H: 4 articles (01/2018 - 01/2007)
2.	Caffrey, Conor R: 4 articles (07/2016 - 01/2007)
3.	Vermeire, Jon J: 2 articles (07/2016 - 01/2012)
4.	Sajid, Mohammed: 2 articles (12/2013 - 01/2007)
5.	Andrade, Rosa M: 1 article (01/2018)
6.	Brenner, Sara B T: 1 article (01/2018)
7.	Chaparro, Juan D: 1 article (01/2018)
8.	Cheng, Timmy: 1 article (01/2018)
9.	Cohn, Shara: 1 article (01/2018)
10.	Hirata, Ken: 1 article (01/2018)

Related Diseases

1.	Chagas Disease (American Trypanosomiasis) 04/01/2015 - "K11777 is already in advanced stages of development for a number of parasitic diseases, such as Chagas disease, and has proven to be safe and effective in a range of animal models. "
2.	Toxoplasmosis 01/01/2018 - "Therefore, K11777 shows promise as a novel therapeutic agent in the treatment of toxoplasmosis, and may prove to be a broadly effective anti-parasitic agent." 01/01/2018 - "In vivo, a single dose of K11777 led to 100% survival of chicken embryos in an model of acute toxoplasmosis (p = 0.015 Cox regression analysis). " 01/01/2018 - "Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis."
3.	Schistosomiasis mansoni 01/01/2007 - "The efficacy of the vinyl sulfone cysteine protease inhibitor K11777 was tested in the murine model of schistosomiasis mansoni. "
4.	Parasitic Diseases (Parasitic Disease) 04/01/2015 - "K11777 is already in advanced stages of development for a number of parasitic diseases, such as Chagas disease, and has proven to be safe and effective in a range of animal models. "
5.	Infections 12/01/2013 - "parvum, oral or intraperitoneal treatment with K11777 for 10 days rescued mice from otherwise lethal infections. " 07/04/2016 - "We previously showed that a single oral 100 mg/kg dose of the cathepsin cysteine protease (CP) inhibitor, K11777, offers near cure of infection that is associated with a 95% reduction in the parasite's resident CP activity. " 01/01/2012 - "Using various life-cycle stages of the hookworm Ancylostoma ceylanicum in vitro and a hamster model of infection, we report the potent, dose-dependent cidal activities of the peptidyl cysteine protease inhibitors (CPIs) K11002 (4-mopholino-carbonyl-phenylalanyl-homophenylalanyl- vinyl sulfone phenyl) and K11777 (N-methylpiperazine-phenylalanyl-homophenylalanyl-vinylsulfone phenyl). "

Related Drugs and Biologics

1.	Cysteine Proteinase Inhibitors
2.	divinyl sulfone
3.	Cathepsins
4.	Cysteine Proteases (Cysteine Protease)
5.	Ceruletide
6.	Anthelmintics
7.	morpholin- urea- phenylalanyl- homophenylalanyl- vinylsulfone- phenyl