CK0106023

is an allosteric inhibitor of KSP motor domain ATPase with a Ki of 12 nM. Among five kinesins tested, CK0106023 was specific for KSP. In tumor-bearing mice.; structure in first source

Also Known As:

CK 0106023

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - CK0106023: 1

Experts

1.	Beraud, Christophe: 1 article (05/2004)
2.	Chabala, John C: 1 article (05/2004)
3.	Crompton, Anne: 1 article (05/2004)
4.	Finer, Jeffrey T: 1 article (05/2004)
5.	Fritsch, Alex: 1 article (05/2004)
6.	Gonzales, Paul: 1 article (05/2004)
7.	Lee, Yan: 1 article (05/2004)
8.	Lewis, Evan: 1 article (05/2004)
9.	Mak, John: 1 article (05/2004)
10.	Moody, Robert: 1 article (05/2004)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2004 - "In tumor-bearing mice, CK0106023 exhibited antitumor activity comparable to or exceeding that of paclitaxel and caused the formation of monopolar mitotic figures identical to those produced in cultured cells. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)