PTEN Phosphohydrolase

A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.

Also Known As:

PTEN Phosphatase; PTEN Protein; MMAC1 Protein; Mutated In Multiple Advanced Cancers 1 Protein; PTEN Protein Phosphatase; Phosphatase and Tensin Homologue on Chromosome Ten Protein; Phosphatase, PTEN; Phosphatase, PTEN Protein; Phosphohydrolase, PTEN; Protein Phosphatase, PTEN

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Monoester Hydrolases: 7477
        PTEN Phosphohydrolase: 865
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - PTEN Phosphohydrolase: 865
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 1683
      - PTEN Phosphohydrolase: 865

Drosophila PTEN protein

Bio-Agent Context: Research Results