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ZJ43

N-acetylaspartylglutamate (NAAG) peptidase inhibitor; structure in first source

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - ZJ43: 5

Experts

1.	Neale, Joseph H: 4 articles (09/2017 - 01/2008)
2.	Olszewski, Rafal T: 3 articles (09/2017 - 01/2008)
3.	Bzdega, Tomasz: 2 articles (09/2017 - 09/2012)
4.	Balasubramanian, Shankar: 1 article (09/2017)
5.	Craddock, Kirsten E: 1 article (09/2017)
6.	Der, Elise K: 1 article (09/2017)
7.	Hark, Timothy J: 1 article (09/2017)
8.	Janczura, Karolina J: 1 article (09/2017)
9.	Moussa, Charbel: 1 article (09/2017)
10.	O'Rourke, Brennen: 1 article (09/2017)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2008 - "To confirm the efficacy of NAAG peptidase inhibition in decreasing motor behaviors induced by PCP and MK-801, ZJ43 was tested in additional schizophrenia models. "
2.	Inflammation (Inflammations) 09/22/2010 - "Systemic injection of ZJ43 proximal to the time of inflammation blocked peripheral inflammation-induced increases in synaptic transmission of this pathway 24 hrs later and blocked the induction of mechanical allodynia that developed by this time point. " 09/12/2012 - "Systemic injection of ZJ43 increased NAAG levels in the PAG and RVM and blocked the inflammation-induced increase in glutamate release in the PAG. " 09/22/2010 - "ZJ43 was much less effective than SLx in reducing eEPSCs 24 hours post inflammation suggesting an inflammation induced reduction in NAAG release or an increase in the ratio of mGluR2 to mGluR3 expression. "
3.	Neoplasms (Cancer) 12/18/2015 - "In a vesicular membrane transport assay, ABCC5 also transported exogenous glutamate analogs, like the classic excitotoxic neurotoxins kainic acid, domoic acid, and NMDA; the therapeutic glutamate analog ZJ43; and, as previously shown, the anti-cancer drug methotrexate. "
4.	Memory Disorders (Memory Loss) 09/01/2017 - "mGluR2 and mGluR3 knock-out (ko) mice were used to test the hypothesis that mGluR3 mediates the activity of GCPII inhibitors ZJ43 and 2-PMPA in animal models of memory and memory loss. "
5.	Hyperalgesia 09/22/2010 - "Systemic injection of ZJ43 proximal to the time of inflammation blocked peripheral inflammation-induced increases in synaptic transmission of this pathway 24 hrs later and blocked the induction of mechanical allodynia that developed by this time point. "

Related Drugs and Biologics

1.	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)
2.	Dizocilpine Maleate (Dizocilpine)
3.	Glutamic Acid (Glutamate)
4.	metabotropic glutamate receptor 2
5.	metabotropic glutamate receptor 3 (mGluR3)
6.	N-Methylaspartate (NMDA)
7.	Neurotoxins
8.	Methotrexate (Mexate)
9.	Kainic Acid (Kainate)
10.	domoic acid