3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy - 1- butenyl)- 3,5- dihydroxycyclopentyl)- 5- heptenoic acid (5Z)-7-((1R,2R

a tafluprost metabolite; structure in first source

Also Known As:

(5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoic acid; 7-(2-(3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoic acid; AFP-172; tafluprost acid

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hara, Hideaki: 2 articles (04/2004 - 12/2003)
2.	Kageyama, Masaaki: 2 articles (04/2004 - 12/2003)
3.	Matsugi, Takeshi: 2 articles (04/2004 - 12/2003)
4.	Matsumura, Yasushi: 2 articles (04/2004 - 12/2003)
5.	Nakajima, Tadashi: 2 articles (04/2004 - 12/2003)
6.	Aihara, Makoto: 1 article (09/2011)
7.	Araie, Makoto: 1 article (09/2011)
8.	Yamagishi, Reiko: 1 article (09/2011)
9.	Gabelt, B'Ann T: 1 article (04/2004)
10.	Kaufman, Paul L: 1 article (04/2004)

Related Diseases

1.	Hypoxia (Hypoxemia) 09/01/2011 - "Our purpose of study is to investigate the direct neuroprotective effect of PG analogues on glutamate- and hypoxia-induced RGC death using rat purified primary RGC culture with latanoprost acid, travoprost acid, bimatoprost acid, bimatoprost, tafluprost acid, unoprostone, and PGF2α. "
2.	Experimental Melanoma 12/01/2003 - "A carboxylic acid of latanoprost (100 microM) significantly increased the melanin content of cultured B16 melanoma cells, but some 15,15-difluoro derivatives, such as AFP-157 and AFP-172, did not. "
3.	Melanoma (Melanoma, Malignant) 04/01/2004 - "In cultured B16-F0 melanoma cells, AFP-172 (100 microM) did not stimulate melanogenesis, but PhXA85 (100 microM) did. "

Related Drugs and Biologics

1.	Latanoprost (Xalatan)
2.	Glutamic Acid (Glutamate)
3.	Neuroprotective Agents
4.	Acids
5.	Bimatoprost (Lumigan)
6.	Travoprost (Travatan)
7.	Melanins (Melanin)
8.	Carboxylic Acids
9.	AFP-157
10.	PhXa 85