HES 130-0.4

6% hydroxyethylstarch (HES) with MW 130 kDa and a very low degree of substitution (Ds 0.4); volume replacement with HES 130/0.4 may reduce the inflammatory response in patients undergoing major abdominal surgery

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Networked: 110 relevant articles (16 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Jiong: 4 articles (03/2015 - 10/2006)
2.	Xu, Jianguo: 4 articles (08/2010 - 09/2006)
3.	Feng, Xiaomei: 4 articles (08/2010 - 09/2006)
4.	Ertmer, Christian: 3 articles (06/2015 - 04/2010)
5.	Xing, Nan: 3 articles (03/2015 - 01/2013)
6.	Van Aken, Hugo: 3 articles (06/2013 - 04/2010)
7.	Neff, Thomas A: 3 articles (01/2013 - 05/2003)
8.	Stocker, Reto: 3 articles (01/2013 - 05/2003)
9.	Li, Jieshou: 3 articles (02/2010 - 04/2009)
10.	Wang, Pengfei: 3 articles (02/2010 - 04/2009)

Related Diseases

1.	Hypotension (Low Blood Pressure) 10/01/2008 - "HES 130/0.4 is more effective than LR to prevent hypotension following spinal anesthesia for CS; its routine use in this purpose should be considered." 06/01/2012 - "However, the efficacy of HES 130/0.4 alone in prevention of maternal hypotension during spinal anaesthesia for caesarean section is still insufficient." 12/01/2014 - "HES 130/0.4 coload reduced the incidence, the duration of longest hypotension, the need for ephedrine and the adverse maternal effects." 06/01/2014 - "The incidence of hypotension was lower after preloading of 500 mL of HES 130/0.4 than preloading with 1500 mL of 9‰ saline solution." 01/01/2011 - "HES 130/0.4 is as useful for hypotension prophylaxis as 5-mg or 10-mg intravenous doses of ephedrine. "
2.	Sepsis (Septicemia) 01/01/2007 - "Infusion of HES 130/0.4 at 4 or 10 hr after the septic insult resulted in the greatest decreases in inflammatory mediators, suggesting that HES 130/0.4 is more protective against pulmonary capillary leakage when given early rather than later during sepsis." 01/01/2012 - "In order to compare the hemodynamic efficacy and safety of 6% HES 130/0.4 and NaCl 0.9% for HDS in patients with severe sepsis, we designed a prospective, multicenter, active-controlled, double-blind, randomized study in intensive care units. " 01/01/2011 - "The 6S trial will provide important safety and efficacy data on the use of HES 130/0.4 in patients with severe sepsis. " 02/01/2010 - "This study showed that moderate doses (15 mL/kg) of HES 130/0.4 administration significantly prevented this intraperitoneal sepsis-induced impaired anastomotic healing of the left colon. " 09/01/2009 - "This study showed that moderate doses (15 ml/kg) of HES 130/0.4 administration significantly prevented this intraperitoneal sepsis-induced impaired anastomotic healing of the left colon. "
3.	Hemorrhagic Shock 09/01/2006 - "In HES 130/0.4 group and HES 200/0.5 group at 90 minutes during hemorrhagic shock, the responses of MAP to NE were improved significantly compared with those of SC group (both P<0.05), plasma contents of NO and NOS were reduced markedly compared with those of SC group (P<0.05 or P<0.01). " 04/01/2009 - "HES 130/0.4 resuscitation prevents HS/R induced intestinal injury by modulating inflammatory response and preventing oxidative stress in a rat model of hemorrhagic shock. " 03/01/2009 - "We conclude that early infusion of Voluven is beneficial for maintenance of the hemodynamic stability and for the balance of cerebral oxygen supply and consumption during the resuscitation of acute hemorrhagic shock." 04/01/2007 - "Efficacy of resuscitation with 6% VOLUVEN plus Ringer's lactate may be better than Ringer's lactate alone in regulating blood coagulation after hemorrhagic shock in rats." 04/01/2008 - "Resuscitation from hemorrhagic shock with HS-HES 200/0.62 results in less impairment of clot formation when compared with compensation of blood loss by administering 6% HES 130/0.4 or 4% gelatin."
4.	Reperfusion Injury 02/01/2009 - "The results of this study showed that 6% HES 130/0.4 solution is more effective in the prevention of ischaemia/reperfusion injury than saline when given in the same volume." 12/04/2007 - "Infusion of 10-20 ml/kg HES (130/0.4) significantly alleviates the ischemia-reperfusion injury, probably by reducing the ICAM-1 expression." 12/04/2007 - "To explore the protective effects of hydroxyethyl starch (HES)(130/0.4) against ischemia reperfusion injury of kidney and its impact on the expression of intercellular adhesion molecule-1 (ICAM-1). " 12/01/2011 - "To investigate whether a third generation colloid, hydroxyethyl starch (HES 130/0.4), used for perioperative fluid therapy, protects the rat liver against the late-phase response of ischemia/reperfusion injury (IRI) and if inhibition of neutrophil hepatic infiltration plays a part in this mechanism. "
5.	Hemorrhage 06/01/2009 - "In the hemorrhage studies, 2-hour survival was 90% with MP4, 50% with controls, and 10% and 0% with HES 260/0.45 and HES 130/0.4, respectively. " 01/01/2006 - "Our study shows that the administration of a moderate dose of HES (130/0.4) in children undergoing cardiac surgery does not cause more bleeding or a higher transfusion requirement than a FFP infusion, and suggests that the administration of 10 ml/kg HES (130/0.4) is a safe alternative to plasma for intravascular volume replacement in this patient population." 09/30/2004 - "Both coagulopathy and clinical bleeding have been documented after administration of either HES 200/0.5 or HES 130/0.4, and the magnitude of negative effects on hemostasis has been similar for these two HES solutions. " 01/01/2015 - "For the in vivo study, rats were subjected to a severe volume-controlled hemorrhage and were resuscitated using a colloid solution (HES 130/0.4, HES 200/0.5, or GEL) or LR. " 01/01/2013 - "The aim of this study was to compare the effects of HES 130/0.4 to lactated Ringer solution during hip arthroplasty in adult patients under spinal anesthesia regarding intraoperative bleeding, hemodynamic parameters, coagulation profile, transfusion requirements and clinical outcomes. "

Related Drugs and Biologics

1.	Hetastarch (Pentastarch)
2.	Sodium Chloride (Saline Solution)
3.	Oxygen
4.	HES 130-0.4
5.	Colloids (Colloid)
6.	Ringer's solution
7.	Lactic Acid
8.	Ephedrine
9.	Ringer's lactate
10.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)

Related Therapies and Procedures

1.	Resuscitation
2.	Cesarean Section (Caesarean Section)
3.	Spinal Anesthesia
4.	Ligation
5.	Hemodilution