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bis-acridine

structure in first source

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - bis-acridine: 3

Experts

1.	Jiang, Jian-Hui: 2 articles (11/2006 - 06/2005)
2.	Lin, Wei-Qi: 2 articles (11/2006 - 06/2005)
3.	Shen, Guo-Li: 2 articles (11/2006 - 06/2005)
4.	Yu, Ru-Qin: 2 articles (11/2006 - 06/2005)
5.	Wu, Hai-Long: 1 article (11/2006)
6.	Zhou, Yan-Ping: 1 article (11/2006)
7.	Zou, Hong-Yan: 1 article (11/2006)
8.	Lin, Li: 1 article (06/2005)
9.	Cohen, Fred E: 1 article (03/2003)
10.	Deady, Leslie W: 1 article (03/2003)

Related Diseases

1.	Scrapie 03/18/2003 - "We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency of bis-acridine compounds. "
2.	Neuroblastoma 03/18/2003 - "We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency of bis-acridine compounds. " 03/18/2003 - "Three bis-acridine analogs, (6-chloro-2-methoxy-acridin-9-yl)-(3-[4-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propyl]-piperazin-1-yl]-propyl)-amine, N,N'-bis-(6-chloro-2-methoxy-acridin-9-yl)-1,8-diamino-3,6-dioxaoctane, and (1-[[4-(6-chloro-2-methoxy-acridin-9-ylamino)-butyl]-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propyl]-carbamoyl]-ethyl)-carbamic acid tert-butyl ester, showed half-maximal inhibition of PrP(Sc) formation at 40, 25, and 30 nM, respectively, and were not cytotoxic to uninfected neuroblastoma cells at concentrations of 500 nM. Our data suggest that bis-acridine analogs may provide a potent alternative to the acridine-based compound quinacrine, which is currently under clinical evaluation for the treatment of prion disease."
3.	Lewis Lung Carcinoma 06/01/2005 - "Quantitative structure-activity relationship (QSAR) model has been formulated for a set of DNA binding topoisomerase (topo) (substituted bis[(acridine-4-carboxamide)propyl]methylamines) on murine Lewis lung carcinoma (LL(c)) cells. "
4.	Prion Diseases (Transmissible Spongiform Encephalopathies) 03/18/2003 - "Three bis-acridine analogs, (6-chloro-2-methoxy-acridin-9-yl)-(3-[4-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propyl]-piperazin-1-yl]-propyl)-amine, N,N'-bis-(6-chloro-2-methoxy-acridin-9-yl)-1,8-diamino-3,6-dioxaoctane, and (1-[[4-(6-chloro-2-methoxy-acridin-9-ylamino)-butyl]-[3-(6-chloro-2-methoxy-acridin-9-ylamino)-propyl]-carbamoyl]-ethyl)-carbamic acid tert-butyl ester, showed half-maximal inhibition of PrP(Sc) formation at 40, 25, and 30 nM, respectively, and were not cytotoxic to uninfected neuroblastoma cells at concentrations of 500 nM. Our data suggest that bis-acridine analogs may provide a potent alternative to the acridine-based compound quinacrine, which is currently under clinical evaluation for the treatment of prion disease."
5.	Leukemia P388 11/01/2006 - "The proposed HPSORBFN algorithm was applied to modeling the inhibitory activities of substituted bis[(acridine-4-carboxamide)propyl]methylamines to murine P388 leukemia cells and the bioactivities of COX-2 inhibitors. "

Related Drugs and Biologics

1.	Acridines
2.	Methylamines
3.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
4.	Quinacrine (Mepacrine)
5.	Esters
6.	DNA (Deoxyribonucleic Acid)
7.	Amines
8.	carbamic acid (ammonium carbamate)
9.	trioctyl phosphine oxide (TOPO)