NNC 55-0396

a calcium channel blocker with high selectivity for CaV3 channels over high voltage activated channels; structure in first source

Also Known As:

(1S,2S)-2-(2-(N-((3-benzimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride; (1S,2S)-2-(2-(N-((3-benzoimidazol-2-yl)propyl)-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl valeroate dihydrochloride; NNC-55-0396

Networked: 21 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kawabata, Atsufumi: 7 articles (06/2019 - 01/2012)
2.	Sekiguchi, Fumiko: 7 articles (06/2019 - 01/2012)
3.	Okawa, Yasumasa: 3 articles (10/2012 - 01/2012)
4.	Nishikawa, Hiroyuki: 2 articles (06/2019 - 10/2012)
5.	Tsubota, Maho: 2 articles (06/2019 - 02/2015)
6.	Kanaoka, Daiki: 2 articles (02/2014 - 02/2013)
7.	Yoshida, Shigeru: 2 articles (02/2014 - 02/2013)
8.	Aoki, Yuka: 2 articles (02/2013 - 07/2012)
9.	Tsubota-Matsunami, Maho: 2 articles (02/2013 - 01/2012)
10.	Matsunami, Maho: 2 articles (10/2012 - 07/2012)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 08/11/2011 - "Together, our study demonstrates the effectiveness of NNC 55-0396 in inhibiting Ca(v)3.2, and then suggests that paclitaxel-evoked neuropathic pain might involve the enhanced activity of T-type calcium channels and/or CSE in rats, but not upregulation of Ca(v)3.2 and CSE at protein levels, differing from the previous evidence for the neuropathic pain model induced by spinal nerve cutting in which Ca(v)3.2 was dramatically upregulated in DRG." 12/16/2016 - "T-type calcium channel blockers (mibefradil, ethosuximide, NNC 55-0396) are of great interest for the development of new symptomatic treatments of neuropathic pain, due to their various effects on pain perception. "
2.	Hyperalgesia 01/01/2012 - "Intracolonic administration of NaHS, an H(2)S donor, evoked visceral pain-like nociceptive behavior and referred hyperalgesia in mice, an effect abolished by NNC 55-0396, a selective T-type Ca(2+)-channel blocker, or by knockdown of Ca(v)3.2. " 01/01/2015 - "Finally, preceding and periodic intraplantar treatment with the T-type calcium channel blockers mibefradil and NNC 55-0396 markedly reduced and reversed mechanical hyperalgesia during the acute and sub-acute phases, respectively, in mice. " 02/28/2014 - "Intraplantar administration of Na2S, like NaHS, caused mechanical hyperalgesia, an effect blocked by NNC 55-0396, a T-channel inhibitor. " 02/01/2013 - "In rats, intraplantar (i.pl.) administration of db-cAMP or PGE(2) caused mechanical hyperalgesia, an effect suppressed by AKAPI, two distinct T-channel blockers, NNC 55-0396 and ethosuximide, or ZnCl(2) , known to inhibit Ca(v) 3.2 among T channels. " 08/11/2011 - "Repeated systemic administration of paclitaxel caused delayed development of mechanical hyperalgesia, which was reversed by single intraplantar administration of NNC 55-0396 or mibefradil, and by silencing of Ca(v)3.2 by antisense oligodeoxynucleotides. "
3.	Tremor (Tremors) 05/20/2011 - "In contrast to mibefradil, NNC 55-0396 is well tolerated and suppresses tremor, and exerts less cytochrome P450 inhibition. " 05/20/2011 - "In the GABAA α1-null model, NNC 55-0396 but not mibefradil, (each at 20mg/kg), suppressed tremor while NNC 55-0396 at 12.5mg/kg suppressed harmaline-induced tremor by half by 20-100min, whereas mibefradil at the same dose did not significantly affect tremor. " 11/01/2010 - "In addition, ECN and NNC 55-0396 suppressed harmaline tremor as well in Cav3.1-null mice as in wild-type mice. " 05/20/2011 - "Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor."
4.	Neoplasms (Cancer) 05/01/2015 - "NNC 55-0396 could be a potential therapeutic drug candidate for cancer treatment." 05/01/2015 - "NNC 55-0396 inhibited tumor-induced angiogenesis in vitro and in vivo by suppressing HIF-1α stability. " 05/01/2015 - "Moreover, NNC 55-0396 significantly suppressed glioblastoma tumor growth in a xenograft model. " 05/01/2022 - "Mibefradil and NNC-55-0396, tetralol derivatives with a proven -ability to block T-type calcium channels in excitable cells, reduce cancer cell viability in vitro, causing cell death. "
5.	Glioblastoma (Glioblastoma Multiforme) 05/01/2015 - "Moreover, NNC 55-0396 significantly suppressed glioblastoma tumor growth in a xenograft model. " 05/01/2022 - "Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1α, JNK1 and calcium signaling."

Related Drugs and Biologics

1.	T-Type Calcium Channels (T-Type Calcium Channel)
2.	Proteins (Proteins, Gene)
3.	Paclitaxel (Taxol)
4.	Mibefradil
5.	sodium bisulfide (NaHS)
6.	Protein Isoforms (Isoforms)
7.	Harmaline
8.	Ethosuximide (Zarontin)
9.	Ascorbic Acid (Vitamin C)
10.	zinc chloride