Pogostone

03/01/2016 - "Protective effects of pogostone against LPS-induced acute lung injury in mice via regulation of Keap1-Nrf2/NF-κB signaling pathways."
09/01/2018 - "Pogostone (PO), a major component of Pogostemon cablin, displays potent protective effects against lipopolysaccharide-induced acute lung injury (ALI) in mice. "
03/01/2016 - "To investigate the potential therapeutic effect of pogostone on lipopolysaccharide (LPS)-induced acute lung injury (ALI), mice were pretreated with pogostone prior to LPS exposure. "

01/01/2015 - "Protective effects of pogostone from Pogostemonis Herba against ethanol-induced gastric ulcer in rats."
01/01/2016 - "The aim was to scientifically evaluate the possible gastroprotective effect and the underlying mechanisms of pogostone against indomethacin-induced gastric ulcer in rats. "
01/01/2016 - "The gastroprotective effect of pogostone from Pogostemonis Herba against indomethacin-induced gastric ulcer in rats."
01/01/2015 - "We examined the protective effect of pogostone (PO), a chemical constituent isolated from Pogostemonis Herba, on the ethanol-induced gastric ulcer in rats. "

04/18/2017 - "In this study, we performed to investigate the anti-colorectal tumor property of Pogostone by inducing aurophagy and apoptosis in human colorectal cancer cells, and to define the potential molecular mechanisms. "
04/18/2017 - "Pogostone showed anti-colorectal tumor effects by inducing autophagy and apoptosis involving PI3K/Akt/mTOR axis. "
04/18/2017 - "Pogostone induces autophagy and apoptosis involving PI3K/Akt/mTOR axis in human colorectal carcinoma HCT116 cells."
04/18/2017 - "In vivo, the anti-tumor effect of pogostone was tested with HCT116 colorectal tumor cells transplantation tumor model. "
01/01/2022 - "Here, we report the cancer prevention and gut microbiota (GM) modulating property of PEO and its derivatives patchouli alcohol (PA) and pogostone (PO) in the ApcMin /+ colorectal cancer mice model. "

04/01/2022 - "In the present study, we investigated the effects of pogostone on ovarian cancer cell lines (OVCAR-3). "
04/01/2022 - "In vitro evaluation of the pogostone effects on the expression of PTEN and DACT1 tumor suppressor genes, cell cycle, and apoptosis in ovarian cancer cell line."

04/18/2017 - "In vivo, 150mg/kg pogostone inhibited the HCT116 tumor growth in immunodeficient mice with an inhibitory rate of 43.3%, decreased the expression of Ki67, and induced apoptosis in three days. "
04/18/2017 - "In vitro, pogostone exhibits significant anti-tumor activity against human cancer cell lines, especially for HCT116 (18.7±1.93μg/ml). "
04/18/2017 - "In vitro, The anti-tumor activity of pogostone was assessed using MTT assay. "
04/18/2017 - "Thus, pogostone may be a promising lead compound to be further developed for cancer therapy."
04/18/2017 - "In vivo, the anti-tumor effect of pogostone was tested with HCT116 colorectal tumor cells transplantation tumor model. "