parathyroid hormone-related protein (1-40)

Also Known As:

PTHrP 1-40

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Parathyroid Hormone-Related Protein: 2289
      - parathyroid hormone-related protein (1-40): 3
- Peptides: 82426
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Parathyroid Hormone-Related Protein: 2289
      - parathyroid hormone-related protein (1-40): 3
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Parathyroid Hormone-Related Protein: 2289
    - parathyroid hormone-related protein (1-40): 3

Experts

1.	Almaden, Yolanda: 1 article (07/2003)
2.	Garfia, Bartolome: 1 article (07/2003)
3.	Lewin, Ewa: 1 article (07/2003)
4.	Olgaard, Klaus: 1 article (07/2003)
5.	Rodriguez, Mariano: 1 article (07/2003)
6.	Almaden, Y: 1 article (07/2000)
7.	Lewin, E: 1 article (07/2000)
8.	Olgaard, K: 1 article (07/2000)
9.	Rodriguez, M: 1 article (07/2000)

Related Diseases

1.	Hypocalcemia 07/01/2003 - "The maximal PTH response to hypocalcemia was enhanced in CRF rats (maximum PTH 382 +/- 58 pg/mL vs. 196 +/- 29 pg/mL in normal rats, P < 0.01) and further enhanced by PTHrP 1-40 to 826 +/- 184 pg/mL (P < 0.01). " 07/01/2000 - "The maximal response of PTH to hypocalcemia (218 +/- 16 pg/mL, N = 6) was significantly enhanced by PTHrP 1-40 (525 +/- 79 pg/mL, N = 6) and by PTHrP 1-86 (465 +/- 29 pg/mL, N = 6, P < 0.001). "
2.	Uremia 07/01/2003 - "After 8 weeks of uremia, the rats were infused with EGTA and PTHrP 1-40 or vehicle. "
3.	Osteosarcoma (Osteogenic Sarcoma) 03/01/1991 - "Two forms of synthetic N-terminal human PTHrp, PTHrp-(1-34) and [Tyr40]PTHrp-(1-40), which are fully active in conventional assays for PTH/PTHrp, were tested for effects in three in vitro bioassay systems for TGF-beta: 1) stimulation, and 2) inhibition, respectively, of epidermal growth factor-dependent soft-agar colony formation of either normal rat kidney-derived fibroblasts (NRK 49F) or human lung carcinoma cells (A549); and 3) biosynthesis of metabolically labeled fibronectin in both NRK 49F cells and clonal osteoblastic rat osteosarcoma cells (ROS 17/2.8). "
4.	Secondary Hyperparathyroidism 07/01/2003 - "Our aim was to search for the PTH/PTHrP receptor in rat parathyroid glands and to examine the effects of PTHrP 1-40 on PTH secretion in in vivo models of secondary hyperparathyroidism (HPT) in uremic rats. "
5.	Carcinoma (Carcinomatosis) 03/01/1991 - "Two forms of synthetic N-terminal human PTHrp, PTHrp-(1-34) and [Tyr40]PTHrp-(1-40), which are fully active in conventional assays for PTH/PTHrp, were tested for effects in three in vitro bioassay systems for TGF-beta: 1) stimulation, and 2) inhibition, respectively, of epidermal growth factor-dependent soft-agar colony formation of either normal rat kidney-derived fibroblasts (NRK 49F) or human lung carcinoma cells (A549); and 3) biosynthesis of metabolically labeled fibronectin in both NRK 49F cells and clonal osteoblastic rat osteosarcoma cells (ROS 17/2.8). "

Related Drugs and Biologics

1.	Transforming Growth Factor beta1 (TGF beta 1)
2.	Type 1 Parathyroid Hormone Receptor (Parathyroid Hormone Receptor)
3.	Parathyroid Hormone-Related Protein
4.	Fibronectins (Fibronectin)
5.	Epidermal Growth Factor (EGF)
6.	Egtazic Acid (EGTA)
7.	Agar
8.	parathyroid hormone-related protein (1-86)