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nutlin 1

an MDM2 antagonist; structure in first source

Also Known As:

nutlin-1

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - nutlin 1: 3
  - Piperazines: 26
    - nutlin 1: 3

Experts

1.	Cortez, Alane Pereira: 1 article (08/2020)
2.	Lião, Luciano Morais: 1 article (08/2020)
3.	Menegatti, Ricardo: 1 article (08/2020)
4.	Valadares, Marize Campos: 1 article (08/2020)
5.	da Silva, Artur Christian Garcia: 1 article (08/2020)
6.	de Carvalho, Flávio Silva: 1 article (08/2020)
7.	de Oliveira Ribeiro, Higor: 1 article (08/2020)
8.	de Ávila, Renato Ivan: 1 article (08/2020)
9.	Cance, William G: 1 article (01/2014)
10.	Conroy, Jeffrey: 1 article (01/2014)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2020 - "Our group designed and synthesized the N-phenyl-piperazine LQFM030 [1-(4-((1-(4-chlorophenyl)-1H-pyrazol-4-yl)methyl) piperazin-1-yl) ethanone], a small molecule derived from molecular simplification of the Nutlin-1, an inhibitor of the human homologue of murine double minute 2 (MDM2) protein that is expressed in several types of cancer. "
2.	Myeloid Leukemia (Leukemia, Myelocytic) 02/01/2012 - "Nutlin-1 strengthened anti-proliferation and differentiation-inducing activity of ATRA in ATRA-treated p-glycoprotein deregulated human myelocytic leukemia cells."
3.	Leukemia 02/01/2012 - "Nutlin-1 might be a useful adjuvant with ATRA for patients with retinoid-resistant leukemia induced by overexpression of p-gp."
4.	Colonic Neoplasms (Colon Cancer) 01/21/2014 - "In addition, a combination of R2 compound with M13 compound that disrupts FAK and Mmd-2 complex or R2 and Nutlin-1 that disrupts Mdm-2 and p53 decreased clonogenicity of HCT116 p53+/+ colon cancer cells more significantly than each agent alone in a p53-dependent manner. "

Related Drugs and Biologics

1.	Proto-Oncogene Proteins c-mdm2
2.	Member 1 Subfamily B ATP Binding Cassette Transporter
3.	Retinoids
4.	Piperazine
5.	LQFM030