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A357300

a tumor suppressor & reversible inhibitor of methionine aminopeptidase-2; structure in first source

Also Known As:

A-357300

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Chlorobenzenes: 5
        A357300: 2
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - Chlorobenzenes: 5
        A357300: 2

Experts

1.	Erickson, Scott A: 2 articles (04/2005 - 11/2003)
2.	Maris, John M: 2 articles (04/2005 - 11/2003)
3.	Sheppard, George S: 2 articles (04/2005 - 11/2003)
4.	Shusterman, Suzanne: 2 articles (04/2005 - 11/2003)
5.	Wang, Jieyi: 2 articles (04/2005 - 11/2003)
6.	Barr, Rosalind: 1 article (04/2005)
7.	King, Rebecca: 1 article (04/2005)
8.	Morowitz, Michael J: 1 article (04/2005)
9.	Pawel, Bruce: 1 article (04/2005)
10.	Rhodin, Nicholas: 1 article (04/2005)

Related Diseases

1.	Neuroblastoma 04/01/2005 - "We have recently shown that a novel, reversible MetAP2 inhibitor, A-357300, significantly inhibits CHP-134-derived neuroblastoma s.c. " 11/15/2003 - "A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models. "
2.	Neoplasms (Cancer) 04/01/2005 - "Lastly, A-357300 caused regression of established tumors in a genetically engineered murine model with progression-free survival in five of eight mice (P < 0.0001). " 11/15/2003 - "A-357300 induces cytostasis by cell cycle arrest at the G(1) phase selectively in endothelial cells and in a subset of tumor cells, but not in most primary cells of nonendothelial type. " 04/01/2005 - "We now show that the combination of A-357300 with cyclophosphamide at the maximal tolerated dose sustained tumor regression with a T/C at day 48 of 0.16 (P < 0.001) in the CHP-134 xenograft model. " 11/15/2003 - "Here we show that a rationally designed reversible MetAP2 inhibitor, A-357300, suppresses tumor growth preclinically without the toxicities observed with TNP-470. "
3.	Sarcoma (Soft Tissue Sarcoma) 11/15/2003 - "A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models. "
4.	Carcinoma (Carcinomatosis) 11/15/2003 - "A-357300 inhibits angiogenesis both in vitro and in vivo and shows potent antitumor efficacy in carcinoma, sarcoma, and neuroblastoma murine models. "

Related Drugs and Biologics

1.	Cyclophosphamide (Cytoxan)
2.	O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)