8-nitroguanosine

structure in first source

Networked: 8 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Guanosine: 1156
        8-nitroguanosine: 8
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Guanosine: 1156
      - 8-nitroguanosine: 8
  - Ribonucleosides: 49
    - Guanosine: 1156
      - 8-nitroguanosine: 8
Organic Chemicals: 133
- Nitro Compounds: 66
  - 8-nitroguanosine: 8

Experts

1.	Akaike, Takaaki: 4 articles (04/2008 - 01/2003)
2.	Akuta, Teruo: 3 articles (04/2008 - 06/2005)
3.	Maeda, Hiroshi: 2 articles (07/2013 - 01/2003)
4.	Okamoto, Tatsuya: 2 articles (04/2008 - 03/2006)
5.	Sawa, Tomohiro: 2 articles (04/2008 - 01/2003)
6.	Yoshitake, Jun: 2 articles (03/2006 - 01/2003)
7.	Zaki, Mohammad Hasan: 2 articles (03/2006 - 06/2005)
8.	Arina, Simón: 1 article (12/2016)
9.	Ferreres, Federico: 1 article (12/2016)
10.	Genieser, Hans-Gottfried: 1 article (12/2016)

Related Diseases

1.	Virus Diseases (Viral Diseases) 01/21/2003 - "NO was generated in excess in lungs of wild-type mice but was eliminated in iNOS-deficient mice after virus infection; this result also correlated well with formation of 8-nitroguanosine and 3-nitrotyrosine. " 01/01/2015 - "In contrast, levels of 8-nitroguanosine (p < 0.05) were significantly reduced, which might be a protective measure as this compound strongly stimulates the generation of superoxide radicals, and its excess is related to pathologies such as microbial (viral) infections and other inflammatory and degenerative disorders. "
2.	Carcinogenesis 04/18/2008 - "These observations suggest that formation of 8-nitroguanosine may contribute to the pathogenesis of inflammation-associated carcinogenesis." 12/07/2016 - "The results show that the intake of red wine and must secondarily reduces oxidative stress and carcinogenesis due to their content of homovanillic acid, as measured by decreases in the plasmatic concentration of 8-hydroxy-2'deoxyguanosine, 8-hydroxyguanine, and 8-nitroguanosine. " 07/01/2013 - "These chemicals function in mutation and carcinogenesis and promote inflammation, in which peroxynitrite (a product of O₂⁻ and NO) activates MMP, damages DNA and RNA, and regenerates 8-nitroguanosine and 8-oxoguanosine. "
3.	Infections 03/01/2006 - "In this review, we discuss the mechanism of nitrative stress occurring during microbial infections, with special emphasis on biological functions of 8-nitroguanosine formed via NO during the host response to pathogens. " 06/01/2005 - "Nitrative stress-mediated 8-nitroguanosine formation during influenza or Sendai virus infection has been the focus of enormous interest because it involves unique biochemical and pharmacological properties such as redox activity and mutagenic potential. " 07/01/2013 - "This review focuses primarily on my own research, including pathogenic mechanisms of microbial infection, vascular permeability in infection and tumors, and effects of nitric oxide (NO), superoxide anion radical (O₂⁻), and 8-nitroguanosine in the enhanced permeability and retention (EPR) effect for the tumor-selective delivery of macromolecular agents (nanomedicines). " 03/01/2006 - "We have observed nitric oxide (NO)-dependent formation of 8-nitroguanosine and 3-nitrotyrosine during microbial infection, and we determined that both 8-nitroguanosine and 3-nitrotyrosine are useful biomarkers of nitrative stress. "
4.	Neoplasms (Cancer) 04/18/2008 - "8-Nitroguanosine is a nitratively modified nucleoside that is formed endogeneously under inflammatory conditions dependent on nitric oxide production, particularly associated with cancer risks. " 07/01/2013 - "This review focuses primarily on my own research, including pathogenic mechanisms of microbial infection, vascular permeability in infection and tumors, and effects of nitric oxide (NO), superoxide anion radical (O₂⁻), and 8-nitroguanosine in the enhanced permeability and retention (EPR) effect for the tumor-selective delivery of macromolecular agents (nanomedicines). "
5.	Inflammation (Inflammations) 04/18/2008 - "These observations suggest that formation of 8-nitroguanosine may contribute to the pathogenesis of inflammation-associated carcinogenesis." 07/01/2013 - "These chemicals function in mutation and carcinogenesis and promote inflammation, in which peroxynitrite (a product of O₂⁻ and NO) activates MMP, damages DNA and RNA, and regenerates 8-nitroguanosine and 8-oxoguanosine. "

Related Drugs and Biologics

1.	3-nitrotyrosine
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Peroxynitrous Acid (Peroxynitrite)
4.	Superoxides (Superoxide)
5.	RNA (Ribonucleic Acid)
6.	Matrix Metalloproteinases (MMPs)
7.	Biomarkers (Surrogate Marker)
8.	Nucleosides
9.	Homovanillic Acid
10.	DNA (Deoxyribonucleic Acid)