rhodacyanine

01/14/2010 - "Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL)."

01/01/2012 - "Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance."
12/15/2000 - "MKT-077, a cationic rhodacyanine dye analogue has been under preclinical cancer therapeutical trials because of its selective toxicity to cancer cells. "
03/01/1999 - "In conclusion, the broad spectrum of cytotoxicity of MKT 077 in the human tumor-cloning assay and the unique mechanism of action of MKT 077 encourage additional preclinical and clinical studies with this compound and other rhodacyanine dyes."
03/01/2012 - "Cationic rhodacyanine dye, MKT-077 has also shown to bind the same region and kill cancer cells selectively. "
01/01/2012 - "MKT-077, a rhodacyanine dye, was shown to produce cancer specific cell death. "

02/01/1996 - "Selective damage to carcinoma mitochondria by the rhodacyanine MKT-077."
05/01/2000 - "A rhodacyanine dye called MKT-077 has shown a highly selective toxicity toward several distinct human malignant cell lines, including bladder carcinoma EJ, and has been subjected to clinical trials for cancer therapy. "
01/01/1999 - "MKT-077 (1-ethyl-2-[[3-ethyl-5-(3-methylbenzothiazolin-2-yliden)]-4- oxothiazolidin-2-ylidenemethyl] pyridinium chloride), a novel rhodacyanine dye in phase I/II clinical trials, may provide a new approach to cancer therapy based on the accumulation in the mitochondria of the cells of certain carcinomas, for example, those of the colon, breast and pancreas. "

01/01/1998 - "In this study, the mitochondrial phototoxicity of the cationic rhodacyanine MKT-077 was investigated by comparing its effects on the inhibition of mitochondrial respiration and the structural integrity of mitochondrial DNA (mtDNA) in the presence and absence of added high-intensity visible light (7.5 J/cm2). "

11/15/2010 - "SSJ-127, a novel antimalarial rhodacyanine derivative, has shown potent antimalarial activity against chloroquine-resistant Plasmodium strains in vitro and subcutaneous administration of SSJ-127 results in a complete cure of a mouse malaria model. "