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propolin C

a PAK1 inhibitor; from Taiwanese propolis; structure in first source

Also Known As:

nymphaeol A

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        propolin C: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        propolin C: 4

Experts

1.	Chen, Chia-Nan: 2 articles (01/2012 - 01/2004)
2.	Chen, Si-Ying: 1 article (01/2018)
3.	Lee, Yi-Chin: 1 article (01/2018)
4.	Leu, Yann-Lii: 1 article (01/2018)
5.	Pai, Jih-Tung: 1 article (01/2018)
6.	Weng, Meng-Shih: 1 article (01/2018)
7.	Hosoya, Takahiro: 1 article (01/2013)
8.	Kumazawa, Shigenori: 1 article (01/2013)
9.	Kunimasa, Kazuhiro: 1 article (01/2013)
10.	Ohta, Toshiro: 1 article (01/2013)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 01/01/2004 - "In the present study, propolin C effectively induced a cytotoxic effect on human melanoma cells, with an IC(50) of about 8.5 microM. " 01/01/2004 - "In conclusion, the isolation and characterization of propolin C from bee propolis are described for the first time, and this compound is a powerful inducer of apoptosis in human melanoma cells." 01/01/2004 - "To address the mechanism of the apoptosis effect of propolin C, we evaluated the effect of propolin C on induction of apoptosis-related proteins in human melanoma cells. " 01/01/2004 - "DNA flow cytometric analysis indicated that propolin C actively induced apoptosis in human melanoma cells and there is a marked loss of cells from the G2/M phase of the cell cycle. " 01/01/2004 - "Propolin C from propolis induces apoptosis through activating caspases, Bid and cytochrome c release in human melanoma cells."
2.	Neoplasms (Cancer) 01/01/2013 - "Okinawan propolis and its major component, nymphaeol-A, may be useful agents for preventing tumor-induced angiogenesis." 01/01/2012 - "Among them, nymphaeol A (3), nymphaeol B (4) and nymphaeol C (7), abundant in Taiwanese propolis, exhibited cytotoxicity against cancer cell lines. "
3.	Lung Neoplasms (Lung Cancer) 01/01/2018 - "Propolin C Inhibited Migration and Invasion via Suppression of EGFR-Mediated Epithelial-to-Mesenchymal Transition in Human Lung Cancer Cells." 01/01/2018 - "Inhibition of cell migration and invasion by propolin C was through the inhibition of EGF/EGFR-mediated signaling pathway, followed by EMT suppression in lung cancer." 01/01/2018 - "In addition, EGF-induced migration and invasion were suppressed by propolin C-treated A549 lung cancer cells. "

Related Drugs and Biologics

1.	Propolis (Bee Bread)
2.	Cytochromes c (Cytochrome c)
3.	Caspases
4.	Proteins (Proteins, Gene)
5.	Epidermal Growth Factor (EGF)
6.	DNA (Deoxyribonucleic Acid)
7.	nymphaeol C