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IFL protocol

chemotherapy protocol consisting of leucovorin, fluorouracil, and irinotecan for treatment of colorectal cancer

Also Known As:

FOLFIRI 1 protocol; FOLFIRI protocol

Networked: 6 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Rogowski, Wojciech: 1 article (01/2016)
2.	Sulżyc-Bielicka, Violetta: 1 article (01/2016)
3.	Kanzaki, Masaki: 1 article (03/2009)
4.	Maeda, Mamoru: 1 article (03/2009)
5.	Miyoshi, Shunsaku: 1 article (03/2009)
6.	Seki, Yukio: 1 article (03/2009)
7.	Ardito, Francesco: 1 article (03/2007)
8.	Barone, Carlo: 1 article (03/2007)
9.	Cassano, Alessandra: 1 article (03/2007)
10.	Giovannini, Ivo: 1 article (03/2007)

Related Diseases

1.	Diarrhea 07/20/2004 - "The current study reports on the bimonthly FOLFIRI protocol consisting of irinotecan with continuous FA/5-FU in five German outpatient clinics, with emphasis on the safety and efficiency, quality of life, management of delayed diarrhea, and secondary resection of regressive liver metastases. " 12/01/2005 - "(6) In two comparative trials of first-line treatment, adjunction of irinotecan to fluorouracil + folinic acid (FOLFIRI protocol) increased the median survival time by about 3 months, to 15-17 months, but increased the incidence of diarrhea, neutropenia, serious cardiovascular disorders and severe thrombosis. "
2.	Thrombosis (Thrombus) 12/01/2005 - "(6) In two comparative trials of first-line treatment, adjunction of irinotecan to fluorouracil + folinic acid (FOLFIRI protocol) increased the median survival time by about 3 months, to 15-17 months, but increased the incidence of diarrhea, neutropenia, serious cardiovascular disorders and severe thrombosis. "
3.	Neutropenia 12/01/2005 - "(6) In two comparative trials of first-line treatment, adjunction of irinotecan to fluorouracil + folinic acid (FOLFIRI protocol) increased the median survival time by about 3 months, to 15-17 months, but increased the incidence of diarrhea, neutropenia, serious cardiovascular disorders and severe thrombosis. "
4.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2016 - "We still do not know whether the presently used protocol of the first-line palliative treatment of disseminated colorectal cancer (FOLFOX/FOLFIRI protocol) allows maximization of therapeutic response and minimization of side effects. " 09/01/2014 - "The Folfiri protocol is often proposed to patients with metastatic colorectal cancer in relapse or treatment failure after the Folfox protocol. " 09/01/2014 - "Aflibercept (Zaltrap, Sanofi Aventis), another VEGF inhibitor, has been authorised in the European Union as an adjunct to the Folfiri protocol in patients with metastatic colorectal cancer in treatment failure or relapse after a first-line regimen including oxaliplatin (Folfox protocol, for example). " 12/01/2005 - "(9) In practice, the first-line treatment for metastatic colorectal cancer appears to be the fluorouracil + folinic acid combination (LV-5FU2 protocol) plus either oxaliplatin (FOLFOX protocol) or irinotecan (FOLFIRI protocol). "
5.	Neoplasm Metastasis (Metastasis) 03/01/2007 - "This study was performed prospectively to assess the effect of systemic chemotherapy (FOLFIRI protocol) in patients with initially unresectable colorectal liver metastases (CRLM) and, after performing liver resection in patients with downsized metastases, to compare the postoperative and long-term results with those of patients with primarily resectable CRLM. " 07/20/2004 - "The current study reports on the bimonthly FOLFIRI protocol consisting of irinotecan with continuous FA/5-FU in five German outpatient clinics, with emphasis on the safety and efficiency, quality of life, management of delayed diarrhea, and secondary resection of regressive liver metastases. "

Related Drugs and Biologics

1.	Irinotecan (Camptosar)
2.	Fluorouracil (Carac)
3.	Leucovorin (Folinic Acid)
4.	Oxaliplatin (Eloxatin)
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
6.	aflibercept

Related Therapies and Procedures

1.	Folfox protocol
2.	Drug Therapy (Chemotherapy)
3.	Palliative Care (Palliative Therapy)