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5- carboxy- 1,1,3,3- tetramethylisoindolin- 2- yloxyl

antioxidant; structure in first source

Also Known As:

CTMIO cpd

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl: 2

Experts

1.	Hosokawa, Kazuyuki: 2 articles (09/2006 - 10/2004)
2.	Bottle, Steven E: 1 article (09/2006)
3.	Gueven, Nuri: 1 article (09/2006)
4.	Lavin, Martin F: 1 article (09/2006)
5.	Luff, John: 1 article (09/2006)
6.	Peng, Cheng: 1 article (09/2006)
7.	Bottle, E Steven: 1 article (10/2004)
8.	Chen, Philip: 1 article (10/2004)
9.	Lavin, F Martin: 1 article (10/2004)

Related Diseases

1.	Lymphoma (Lymphomas) 09/15/2006 - "We demonstrate here that the antioxidant 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl (CTMIO) dramatically delays the onset of thymic lymphomas in Atm(-/-) mice which is not due to an enhancement of apoptosis by CTMIO. "
2.	Ataxia Telangiectasia (Louis Bar Syndrome) 10/01/2004 - "Three water-soluble carboxy nitroxide antioxidants, 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl, 4-carboxy-2,2,6,6-tetramethylpiperidin-1-yloxyl, and 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl, show significant impact on the postirradiation survival rates of ataxia telangiectasia (A-T) cells compared to normal cells, an assay which represents a model for understanding the impact of ROS damage on the A-T phenotype. "

Related Drugs and Biologics

1.	Antioxidants
2.	3- carboxy- 2,2,5,5- tetramethylpyrrolidin- 1- yloxyl
3.	nitroxyl