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6- diphenylmethyl- 5- (5- isopropyl- 2- methoxybenzylamino)- 1- azabicyclo(2.2.2)octane- 3- carboxylic acid

Subscribe to New Research on 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid

Also Known As:

CJ 12,255; CJ 12255; CJ-12,255; CJ-12255; CJ12,255; CJ12255

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Cyclic Hydrocarbons: 3
    - Bridged Compounds: 3
      - Bicyclo Compounds
        Heterocyclic Bicyclo Compounds
        6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid: 4
Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Heterocyclic Bicyclo Compounds
    - 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid: 4
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bicyclo Compounds
    - 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid: 4
Polycyclic Compounds: 56
- Bridged Compounds: 3
  - Bicyclo Compounds
    - Heterocyclic Bicyclo Compounds
      - 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid: 4

Experts

1.	Pothoulakis, Charalabos: 4 articles (11/2010 - 04/2006)
2.	Zhao, Dezheng: 4 articles (11/2010 - 04/2006)
3.	Koon, Hon-Wai: 3 articles (08/2008 - 04/2006)
4.	Moyer, Mary P: 3 articles (08/2008 - 04/2006)
5.	Xu, Hua: 2 articles (11/2010 - 08/2008)
6.	Zhan, Yanai: 2 articles (02/2007 - 04/2006)
7.	Koon, Hon Wai: 1 article (11/2010)
8.	Fazelbhoy, Zafeer: 1 article (11/2010)
9.	Shih, David: 1 article (11/2010)
10.	Karagiannides, Iordanes: 1 article (11/2010)

Related Diseases

1.	Colitis 02/06/2007 - "administration of CJ-12,255 for 5 days post-DSS suppressed Akt activation, exacerbated colitis, and enhanced apoptosis, and pharmacologic inhibition of Akt, either alone or together with CJ-12,255, produced a similar effect. " 04/15/2006 - "Lastly, COX-2 expression was elevated in colon of mice during experimental colitis, and this effect was normalized by administration of the NK-1R antagonist CJ-12,255. " 08/01/2008 - "Both the degree of angiogenesis and CCN1 expression were elevated in the colons of mice with dextran sodium sulfate-induced colitis, which was reduced by treatment with the NK-1R antagonist CJ-12255. "
2.	Inflammation 11/01/2010 - "Treatment of TNBS-exposed WT mice with the NK-1R antagonist CJ-12255 reduced colonic inflammation, colonic fibrosis, fibroblast accumulation, and expression levels of the fibrogenic factors. "
3.	Fibrosis (Cirrhosis) 11/01/2010 - "Treatment of TNBS-exposed WT mice with the NK-1R antagonist CJ-12255 reduced colonic inflammation, colonic fibrosis, fibroblast accumulation, and expression levels of the fibrogenic factors. "

Related Drugs and Biologics

1.	Dextrans (Dextran)
2.	sodium sulfate (sodium bisulfate)