HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

fluoresceinyl- arginyl- glutamyl- aspartyl- glutamyl- aspartyl- glutamyl- isoleucyl- glutamyl- tryptophan

binds and stabilizes the tumor suppressor p53 core domain, thereby preventing denaturation; may serve as an antineoplastic agent

Also Known As:

Fl-CDB3; fluoresceinyl-Arg-Glu-Asp-Glu-Asp-Glu-Ile-Glu-Trp; fluoresceinyl-REDEDEIEW

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bozko, Przemyslaw: 1 article (11/2003)
2.	Fersht, Alan R: 1 article (11/2003)
3.	Friedler, Assaf: 1 article (11/2003)
4.	Issaeva, Natalia: 1 article (11/2003)
5.	Selivanova, Galina: 1 article (11/2003)
6.	Wiman, Klas G: 1 article (11/2003)

Related Diseases

1.

Neoplasms (Cancer)

11/11/2003 - "Fl-CDB3 sensitized cancer cells that carried wild-type p53 to p53-dependent gamma-radiation-induced apoptosis. "
11/11/2003 - "To test whether the peptides could act as chaperones and rescue the tumor-suppressing function of oncogenic mutants of p53 in living cells, we treated human tumor cells with the fluorescein-labeled peptide Fl-CDB3 (fluorescent derivative of CDB3). "

Related Drugs and Biologics

1.	Fluorescein (Funduscein)
2.	Peptides (Polypeptides)