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6- ethoxy- 3- (4- methanesulfonylphenyl)- 4- phenylpyran- 2- one

a cyclooxygenase-2 inhibitor; structure in first source

Also Known As:

6-ethoxy-MSPPP

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Pyrones: 35
      - 6-ethoxy-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-one: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - 6-ethoxy-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-one: 1

Experts

1.	Amini, Mohsen: 1 article (11/2003)
2.	Habeeb, Amgad G: 1 article (11/2003)
3.	Knaus, Edward E: 1 article (11/2003)
4.	Li, Huiying: 1 article (11/2003)
5.	Praveen Rao, P N: 1 article (11/2003)

Related Diseases

1.

Inflammation (Inflammations)

11/06/2003 - "In contrast, the less potent (IC(50) = 0.10 muM), and less selective (SI = 2880) COX-2 inhibitor 6-ethoxy-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-one (14i) exhibited good antiinflammatory activity where a 1 mg/kg oral dose reduced inflammation 32 and 67% at 3 and 5 h postdrug administration relative to the reference drug celecoxib where a 50 mg/kg oral dose reduced inflammation by 79 and 58% at the respective 3 and 5 h time periods. "

Related Drugs and Biologics

1.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
2.	Celecoxib (Celebrex)