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5,6-secosterol

ozonolysis product of cholesterol; structure in first source

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Sterols: 2245
        5,6-secosterol: 4
Lipids: 114793
- Membrane Lipids: 1591
  - Sterols: 2245
    - 5,6-secosterol: 4

Experts

1.	Augusto, Ohara: 1 article (10/2018)
2.	Chaves-Filho, Adriano B: 1 article (10/2018)
3.	Coelho, Fernando R: 1 article (10/2018)
4.	Dantas, Lucas S: 1 article (10/2018)
5.	Genaro-Mattos, Thiago C: 1 article (10/2018)
6.	Miyamoto, Sayuri: 1 article (10/2018)
7.	Porter, Ned A: 1 article (10/2018)
8.	Tallman, Keri A: 1 article (10/2018)
9.	Betti, Michele: 1 article (07/2015)
10.	Canonico, Barbara: 1 article (07/2015)

Related Diseases

1.	Atherosclerosis 12/01/2006 - "In the present study, we measured the antibody-catalyzed 03 formation from THP-1 monocytes activated by phorbol myristate acetate (PMA) by indigo carmine bleaching reaction test, and the accumulation of cholesterol in THP-1 monocytes by fluorescence spectrophotometric method, and analyzed the cholesterol ozonation product 5,6-secosterol by high-performance liquid chromatography (HPLC), to explore the potential effect of antibody-catalyzed water oxidation on pathogenesis of atherosclerosis. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 10/01/2018 - "Cholesterol 5,6-secosterol aldehydes (Seco A and Seco B) are reported to contribute to neurodegenerative disease pathology by inducing protein modification and aggregation. "
3.	Inflammation (Inflammations) 07/29/2011 - "Herein we show that the inflammation-derived cholesterol 5,6-secosterol aldehydes, atheronal-A (KA) and -B (ALD), but not the polyunsaturated fatty acid (PUFA)-derived aldehydes 4-hydroxynonenal (HNE) and 4-hydroxyhexenal (HHE), induce misfolding of wild-type p53 into an amyloidogenic form that binds thioflavin T and Congo red dyes but cannot bind to a consensus DNA sequence. "
4.	Cardiovascular Diseases (Cardiovascular Disease) 07/01/2015 - "This may contribute to pro-atherogenic and pro-thrombotic mechanisms of 5,6-secosterol and highlights the role of cholesterol autoxidation in cardiovascular disease. "

Related Drugs and Biologics

1.	Cholesterol
2.	Tetradecanoylphorbol Acetate
3.	Indigo Carmine (Indigo Blue)
4.	Aldehydes
5.	Proteins (Proteins, Gene)
6.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
7.	Coloring Agents (Dyes)
8.	Congo Red
9.	atheronal-A
10.	4-hydroxyhexenal