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3- (5,6,7,13- tetrahydro- 9- ((1- methylethoxy)methyl)- 5- oxo- 12H- indeno(2,1- a)pyrrolo(3,4- c)carbazol- 12- yl)propanol
has antineoplastic and antiangiogenic activities; inhibits VEGF-R2 tyrosine kinase; structure in first source
Also Known As:
CEP 5214; CEP-5214; CEP5214
Networked:
1
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Carbazoles: 32
3-(5,6,7,13-tetrahydro-9-((1-methylethoxy)methyl)-5-oxo-12H-indeno(2,1-a)pyrrolo(3,4-c)carbazol-12-yl)propanol: 1
3-Ring Heterocyclic Compounds
Carbazoles: 32
3-(5,6,7,13-tetrahydro-9-((1-methylethoxy)methyl)-5-oxo-12H-indeno(2,1-a)pyrrolo(3,4-c)carbazol-12-yl)propanol: 1
Experts
1.
Hunter, Kathryn
: 1 article (07/2006)
2.
Jones-Bolin, Susan
: 1 article (07/2006)
3.
Klein-Szanto, Andres
: 1 article (07/2006)
4.
Ruggeri, Bruce
: 1 article (07/2006)
5.
Zhao, Hugh
: 1 article (07/2006)
Related Diseases
1.
Neoplasms (Cancer)
07/01/2006 - "
CEP-7055, a fully synthetic, orally active N,N-dimethylglycine ester of CEP-5214, a C3-(isopropylmethoxy)-fused pyrrolocarbazole with potent pan-vascular endothelial growth factor receptor (VEGFR) kinase inhibitory activity, has recently completed phase I clinical trials in cancer patients.
"
Related Drugs and Biologics
1.
Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
2.
Phosphotransferases (Kinase)
3.
Esters
4.
N,N-dimethylglycine 3- (5,6,7,13- tetrahydro- 9- ((1- methylethoxy)methyl)- 5- oxo- 12H- indeno(2,1- a)pyrrolo(3,4- c)carbazol- 12- yl)propyl ester
5.
dimethylglycine