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ZM323881

inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity; structure in first source

Also Known As:

5-((7-(benzyloxy)quinazolin-4-yl)amino)-4-fluoro-2-methylphenol

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - ZM323881: 3

Experts

1.	Chen, Li-Ping: 1 article (01/2022)
2.	Chen, Xue-Tai: 1 article (01/2022)
3.	Fan, Li-Jun: 1 article (01/2022)
4.	Kan, Hou-Ming: 1 article (01/2022)
5.	Shen, Wen: 1 article (01/2022)
6.	Sun, Yuan-Yuan: 1 article (01/2022)
7.	Ablonczy, Zsolt: 1 article (04/2014)
8.	Alsarraf, Oday: 1 article (04/2014)
9.	Crosson, Craig E: 1 article (04/2014)
10.	Dahrouj, Mohammad: 1 article (04/2014)

Related Diseases

1.	Retinal Neovascularization 07/23/2008 - "Orally active anti-VEGF agents including sunitinib and ZM323881 effectively block hypoxia-induced retinal neovascularization. "
2.	Hyperalgesia 01/01/2022 - "Mice after LLC injection demonstrated mechanical allodynia and thermal hyperalgesia, both of which were suppressed via anti-VEGF-A antibody or ZM323881. "
3.	Blister (Bulla) 04/09/2014 - "Control subretinal blebs (1-5 μL) and blebs containing VEGF (1-100 μg/mL), placental growth factor (PlGF; 100 μg/mL), or albumin (100-1000 μg/mL) were injected into New Zealand White or Dutch Belted rabbits with IOP maintained at 10, 15, or 20 mm Hg. One-hour intravitreal pretreatment with ZM323881 (10 μM/L) was used to inhibit the VEGF response. "
4.	Hypoxia (Hypoxemia) 07/23/2008 - "Orally active anti-VEGF agents including sunitinib and ZM323881 effectively block hypoxia-induced retinal neovascularization. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Dihydrotachysterol (AT 10)
4.	Albumins
5.	Sunitinib (Sutent)