Thrombogen

08/01/2008 - "Induction of tumor vasculature occlusion by targeting a thrombogen to newly formed blood vessels in tumor tissues represents an intriguing approach to the eradication of primary solid tumors. "
12/01/2005 - "A selective tumor microvasculature thrombogen that targets a novel receptor complex in the tumor angiogenic microenvironment."
07/01/2004 - "The principles are addressed from the perspective of protein structural design for a class of selective tumor vascular thrombogen proteins that, through interaction with tumor angiogenic endothelium, elicit thrombotic occlusion rather than apoptosis or arrest of angiogenesis. "
07/01/2004 - "To advance this strategy, we describe a design of an integrin targeting selective tumor vascular thrombogen. "
10/01/2002 - "To assess the functional potential of such PSMA-lined microvasculature to selectively direct infarctive tumor therapy, we coupled the soluble extracellular domain of tissue factor to a PSMA catalytic site inhibitor to create a PSMA-directed selective tumor vascular thrombogen (STVT). "

01/24/1997 - "This truncated form of tissue factor (tTF) had limited ability to initiate thrombosis when free in the circulation, but became an effective and selective thrombogen when targeted to tumor endothelial cells. "