respiratory complex II

isolated from small muscle biopsy samples. transfers electrons to ubiquinone; an energy-conserving NADH dehydrogenase

Networked: 15 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Multienzyme Complexes: 8
    - Succinate Cytochrome c Oxidoreductase: 31
      - Electron Transport Complex II: 20
        respiratory complex II: 15
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Succinate Cytochrome c Oxidoreductase: 31
      - Electron Transport Complex II: 20
        respiratory complex II: 15
    - Oxidoreductases Acting on CH-CH Group Donors
      - Electron Transport Complex II: 20
        respiratory complex II: 15
  - Multienzyme Complexes: 8
    - Electron Transport Chain Complex Proteins
      - Electron-Transferring Flavoproteins: 82
        Electron Transport Complex II: 20
        respiratory complex II: 15
      - Succinate Cytochrome c Oxidoreductase: 31
        Electron Transport Complex II: 20
        respiratory complex II: 15
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Li, Jie: 1 article (11/2021)
2.	Liu, Jun: 1 article (11/2021)
3.	Tuo, Zhan: 1 article (11/2021)
4.	Zong, Yan: 1 article (11/2021)
5.	Belyaeva, Elena A: 1 article (12/2018)
6.	Bousquet, Paula A: 1 article (01/2018)
7.	Jeppesen Edin, Nina F: 1 article (01/2018)
8.	Krengel, Ute: 1 article (01/2018)
9.	Sandvik, Joe Alexander: 1 article (01/2018)
10.	Alves-Guerra, Marie-Clotilde: 1 article (01/2017)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 10/01/2015 - "In the present study, two oxidative stress parameters, reactive oxygen species (ROS) and mitochondrial respiratory complex II, were evaluated in the mitochondria of hepatocellular carcinoma (HCC) cells to determine the association between these parameters and the carcinogenesis and clinical outcome of HCC. " 12/01/2018 - "In the present work we studied action of several inhibitors of respiratory complex II (CII) of mitochondrial electron transport chain, namely malonate and thenoyltrifluoroacetone (TTFA) on Cd2+-induced toxicity and cell mortality, using two rat cell lines, pheochromocytoma PC12 and ascites hepatoma AS-30D and isolated rat liver mitochondria (RLM). "
2.	Carcinogenesis 10/01/2015 - "In the present study, two oxidative stress parameters, reactive oxygen species (ROS) and mitochondrial respiratory complex II, were evaluated in the mitochondria of hepatocellular carcinoma (HCC) cells to determine the association between these parameters and the carcinogenesis and clinical outcome of HCC. "
3.	Lung Neoplasms (Lung Cancer) 11/01/2021 - "This study aimed to investigate the role of succinate dehydrogenase 5 (SDH5), an enzyme required for assembling respiratory complex II in lung cancer patients with diabetes. "
4.	Neoplasms (Cancer) 01/01/2023 - "Altered respiratory complex II function has been implicated in cancer, diabetes, and inflammation, but regulatory mechanisms are incompletely understood. " 12/28/2014 - "Owing to ROS inducing activity of TPGS with mitochondrial respiratory complex II, ROS regeneration was observed for TBH nanosystem both in MCF-7/ADR cells and tumor tissues xenografted with MCF-7/ADR cells. " 12/15/2014 - "TRAP1 is a mitochondrial chaperone highly expressed in many tumor types; it inhibits respiratory complex II, down-modulating its succinate dehydrogenase (SDH) enzymatic activity. " 03/01/2009 - "Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II."
5.	Hypoxia (Hypoxemia) 02/01/2014 - "Hypoxia specifically lowered the training-induced expression of markers of respiratory complex II and IV (i.e. " 11/01/2013 - "Type II Fp of human mitochondrial respiratory complex II and its role in adaptation to hypoxia and nutrition-deprived conditions." 01/01/2018 - "Here, we confirm hypoxia-induced expression of the NeuGc GM3 ganglioside also in HeLa cells and reveal several candidate proteins, in particular GM3 synthase and subunit B of respiratory complex II (SDHB), that may be involved in the generation of NeuGc GM3 by SILAC-based proteome analysis. "

Related Drugs and Biologics

1.	Succinate Dehydrogenase (Fumarate Reductase)
2.	Enzymes
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Peroxisome Proliferator-Activated Receptors (PPAR)
5.	Proteome
6.	Succinic Acid (Succinate)
7.	Thenoyltrifluoroacetone
8.	Proteins (Proteins, Gene)
9.	Glutamine (L-Glutamine)
10.	G(M3) Ganglioside