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N,N'- dicyclopentyl- 2- methylsulfanyl- 5- nitro- pyrimidine- 4,6- diamine

structure in first source

Also Known As:

GS39783

Networked: 9 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclopentanes: 58
        N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine: 9
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine: 9

Experts

1.	Pilc, Andrzej: 2 articles (01/2019 - 09/2015)
2.	Wierońska, Joanna M: 2 articles (01/2019 - 09/2015)
3.	Woźniak, Monika: 2 articles (01/2019 - 09/2015)
4.	Froestl, Wolfgang: 2 articles (01/2010 - 09/2004)
5.	Cryan, John F: 2 articles (04/2008 - 09/2004)
6.	Cieślik, Paulina: 1 article (01/2019)
7.	Kalinowski, Leszek: 1 article (01/2019)
8.	Kusek, Magdalena: 1 article (01/2019)
9.	Pelikant-Małecka, Iwona: 1 article (01/2019)
10.	Płoska, Agata: 1 article (01/2019)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 09/01/2015 - "GS39783 and CDPPB, positive allosteric modulators of GABAB and mGlu5 receptors, were previously shown to reverse behavioral phenotypes in animal models to mimic selected (predominantly positive) symptoms of schizophrenia. " 01/01/2019 - "This study was aimed to assess the role of muscarinic and GABAB receptor interactions in animal models of schizophrenia, using positive allosteric modulators (PAMs) of GABAB receptor (GS39783), muscarinic M4 (VU0152100) and M5 (VU0238429) receptor, and partial allosteric agonist of M1 receptor (VU0357017). "
2.	Gastroesophageal Reflux (GERD) 01/01/2010 - "This chapter presents new clinical applications of the prototypic GABA(B) receptor agonist baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine, morphine, and heroin, a novel baclofen prodrug Arbaclofen placarbil, the GABA(B) receptor agonist AZD3355 (Lesogabaran) currently in Phase 2 clinical trials for the treatment of gastroesophageal reflux disease, and four positive allosteric modulators of GABA(B) receptors (CGP7930, GS39783, NVP-BHF177, and BHFF), which have less propensity for the development of tolerance due to receptor desensitization than classical GABA(B) receptor agonists. "
3.	Alcoholism (Alcohol Abuse) 08/01/2012 - "Further study of GS39783 is warranted as it may be a more tolerable treatment for alcoholism than full agonists, due to its behavioral efficacy at doses that lack sedative side effects. "
4.	Stupor 09/01/2004 - "Unlike baclofen and/or the benzodiazepine chlordiazepoxide, GS39783 had no effect in any of the tests for locomotion, cognition, temperature, or narcosis. "
5.	Substance-Related Disorders (Drug Abuse) 01/05/2017 - "These data demonstrate that CGP7930 and GS39783 can trigger ERK1/2 signalling, a critical modulator of mood and drug addiction, independently of an action on GABAB receptors."

Related Drugs and Biologics

1.	Baclofen
2.	2,6- di- tert- butyl- 4- (3- hydroxy- 2,2- dimethylpropyl)phenol
3.	GABA-B Receptor Agonists
4.	GABA-B Receptors
5.	Nicotine
6.	N- (bicyclo(2.2.1)hept- 2- yl)- 2- methyl- 5- (4- (trifluoromethyl)phenyl)- 4- pyrimidinamine
7.	Cholinergic Agents (Cholinergics)
8.	Prodrugs
9.	Morphine (MS Contin)
10.	Hypnotics and Sedatives (Sedatives)

Related Therapies and Procedures

1.	Traction
2.	Self Administration (Administration, Self)