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1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate

an Akt inhibitor; antineoplastic agent

Also Known As:

1L-6-hydroxymethyl-chiro-inositol 2-O-methyl-3-O-octadecylcarbonate; HCIMOC cpd; LY 294005; LY-294005; LY294005

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Sugar Alcohols: 143
    - Inositol: 2982
      - 1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate: 2
Carbohydrates: 22023
- Sugar Alcohols: 143
  - Inositol: 2982
    - 1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate: 2

Experts

1.	Fujiwara, Keishi: 1 article (10/2007)
2.	Iwado, Eiji: 1 article (10/2007)
3.	Kondo, Seiji: 1 article (10/2007)
4.	Kondo, Yasuko: 1 article (10/2007)
5.	Mills, Gordon B: 1 article (10/2007)
6.	Sawaya, Raymond: 1 article (10/2007)
7.	Boulikas, Teni: 1 article (11/2006)
8.	Erdmann, Ruediger: 1 article (11/2006)
9.	Fedier, Andre: 1 article (11/2006)
10.	Fink, Daniel: 1 article (11/2006)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2006 - "Potential of the Akt inhibitor LY294005 to antagonize the efficacy of Cisplatin against HCT116 tumor cells in a DNA mismatch repair-dependent manner."
2.	Adenocarcinoma 11/01/2006 - "Human colorectal adenocarcinoma sublines either deficient (HCT116+ch2) or proficient (HCT116+ch3) in the function of MLH1, one of five proteins crucial to DNA mismatch repair (MMR), were used to investigate whether the Akt-specific inhibitor LY294005 could not only increase the efficacy of platinum drugs in HCT116 cells in general but also increase the efficacy of the cisplatinum compounds Cisplatin and Lipoplatin specifically in MLH1-deficient, Cisplatin- and Lipoplatin-resistant HCT116 cells. "
3.	Glioma (Gliomas) 10/01/2007 - "The purpose of our study was therefore to determine whether and by which mechanisms an Akt inhibitor, 1L-6-hydroxymethyl-chiro-inositol 2(R)-2-O-methyl-3-O-octadecylcarbonate, had anticancer and radiosensitizing effects on malignant glioma U87-MG and radioresistant U87-MG cells with a consistitutively active form of epidermal growth factor receptor (U87-MGDeltaEGFR). "

Related Drugs and Biologics

1.	A-Form DNA (A-DNA)
2.	Proteins (Proteins, Gene)
3.	Platinum
4.	Cisplatin (Platino)
5.	lipoplatin
6.	ErbB Receptors (EGF Receptor)
7.	Radiation-Sensitizing Agents