sinuleptolide

06/01/2016 - "In a cell viability assay, we found that sinuleptolide is dose-responsively antiproliferative against oral gingival cancer Ca9-22 cells but less harmful to normal human gingival fibroblast (HGF-1) cells (P<0.001). "
07/01/2012 - "Sinuleptolide has been demonstrated to possess anti-cancer cell activities; however, the mechanisms underlying the anti-skin cancer effects of 5-epi-sinuleptolide and sinuleptolide remain poorly understood. "

01/01/2017 - "This showed that the cell-killing mechanism of oral cancer cells of sinuleptolide is ROS dependent."
01/01/2017 - "The functional role of oxidative stress in the cell-killing effect of sinuleptolide on oral cancer cells was not investigated as yet. "
01/01/2017 - "We previously reported that the soft coral-derived bioactive substance, sinuleptolide, can inhibit the proliferation of oral cancer cells in association with oxidative stress. "
06/01/2016 - "Sinuleptolide can induce an antiproliferation of oral cancer Ca9-22 cells involving apoptosis, oxidative stress and DNA damage, suggesting that sinuleptolide represents a potential chemotherapeutic drug for oral cancer treatment."
06/01/2016 - "We evaluate the potential anti-oral cancer effects of sinuleptolide and investigate the possible mechanisms involved. "

07/01/2012 - "5-epi-Sinuleptolide inhibited human skin cancer cell growth more than did sinuleptolide. "
07/01/2012 - "Sinuleptolide has been demonstrated to possess anti-cancer cell activities; however, the mechanisms underlying the anti-skin cancer effects of 5-epi-sinuleptolide and sinuleptolide remain poorly understood. "