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(2- (5- amino- 2- (4- fluorophenyl)- 1,6- dihydro- 6- oxo- 1- pyrimidinyl)- N- (1- ((5- methoxycarbonyl- 2- benzoxazolyl)carbonyl)- 2- phenylethyl)acetamide)

structure in first source

Also Known As:

Y-40613

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - (2-(5-amino-2-(4-fluorophenyl)-1,6-dihydro-6-oxo-1-pyrimidinyl)-N-(1-((5-methoxycarbonyl-2-benzoxazolyl)carbonyl)-2-phenylethyl)acetamide): 1
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Acetamides: 21
        (2-(5-amino-2-(4-fluorophenyl)-1,6-dihydro-6-oxo-1-pyrimidinyl)-N-(1-((5-methoxycarbonyl-2-benzoxazolyl)carbonyl)-2-phenylethyl)acetamide): 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzoxazoles: 68
      - (2-(5-amino-2-(4-fluorophenyl)-1,6-dihydro-6-oxo-1-pyrimidinyl)-N-(1-((5-methoxycarbonyl-2-benzoxazolyl)carbonyl)-2-phenylethyl)acetamide): 1

Experts

1.	Imada, Teruaki: 1 article (11/2002)
2.	Kobayashi, Fujio: 1 article (11/2002)
3.	Komorita, Naruyasu: 1 article (11/2002)
4.	Kondo, Takao: 1 article (11/2002)
5.	Miyazaki, Mizuo: 1 article (11/2002)
6.	Naito, Koji: 1 article (11/2002)
7.	Nakamura, Norifumi: 1 article (11/2002)
8.	Yoshikawa, Tsutomu: 1 article (11/2002)

Related Diseases

1.	Pruritus (Itching) 11/01/2002 - "Taken together, these findings suggest that the specific chymase inhibitor Y-40613 may ameliorate symptoms of AD through the dual inhibition of the chymase-dependent IgE production pathway and itching sensation." 11/01/2002 - "We found that Y-40613 (2-[5-amino-2-(4-fluorophenyl)-1,6-dihydro-6-oxo-1-pyrimidinyl]-N-[1-[(5-methoxycarbonyl-2-benzoxazolyl)carbonyl]-2-phenylethyl]acetamide) dose-dependently suppressed the scratching response in a mouse pruritus model, with inhibitory efficacy enhanced by combination with conventional drugs, suggesting that chymase contributes to the development of pruritus by a unique mechanism or mechanisms. "
2.	Contact Dermatitis (Eczema, Contact) 11/01/2002 - "Furthermore, Y-40613 lowered ear thickness as well as serum IgE level in a mouse contact dermatitis model. "

Related Drugs and Biologics

1.	Chymases (Chymase)
2.	Immunoglobulin E (IgE)
3.	acetamide