bicyclol

an antihepatitis drug, on the metabolism and hepatotoxicity of aflatoxin B1 (AFB1) in rats.

Also Known As:

4,4'-bi-(1,3-benzodioxole)-5-carboxylic acid, 5'-(hydroxymethyl)-7,7'-dimethoxy-, methyl ester; 6-methoxycarbonyl-6'-hydroxymethyl-2,3,2',3'-bis(methylenedioxy)-4,4'-dimethoxybiphenyl

Networked: 96 relevant articles (21 outcomes, 30 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        bicyclol: 96

Experts

1.	Li, Yan: 18 articles (11/2020 - 06/2002)
2.	Liu, Geng-Tao: 6 articles (06/2009 - 06/2004)
3.	Lan, Pei: 5 articles (06/2022 - 06/2007)
4.	Li, Hu: 5 articles (06/2022 - 01/2018)
5.	Sheng, Li: 5 articles (04/2017 - 11/2008)
6.	Liu, Geng Tao: 5 articles (01/2009 - 08/2005)
7.	Jiang, Jian-Dong: 4 articles (06/2022 - 01/2018)
8.	Peng, Zong-Gen: 4 articles (06/2022 - 01/2018)
9.	Chen, Hui: 4 articles (04/2017 - 05/2008)
10.	Yao, Xiao-Min: 4 articles (01/2016 - 07/2009)

Related Diseases

1.	Chronic Hepatitis B 06/13/2019 - "Histological improvement in chronic hepatitis B patients treated with bicyclol: real world experience." 10/18/2006 - "To study the benefits and harms of bicyclol for patients with chronic hepatitis B. " 09/01/2005 - "[Histological study of livers from the patients with chronic hepatitis B treated with bicyclol]." 12/01/2007 - "Bicyclol is used for the treatment of chronic hepatitis B in China. " 06/01/2007 - "To evaluate the efficacy and safety of bicyclol for chronic hepatitis B. "
2.	Non-alcoholic Fatty Liver Disease 06/01/2022 - "The present results revealed that bicyclol exerted significant protective effects against HFD-induced NAFLD/NASH. " 09/01/2021 - "Bicyclol ameliorates nonalcoholic fatty liver disease in mice via inhibiting MAPKs and NF-κB signaling pathways." 01/01/2023 - "In our previous studies, we found that bicyclol had beneficial effects on NAFLD/ NASH. " 06/01/2022 - "Therefore, the present study was performed to investigate the protective effect and underlying mechanisms of bicyclol action on NAFLD/NASH. " 09/01/2021 - "In this study, NAFLD model was established by feeding mice with high fat diet (HFD) for 16 weeks, and bicyclol (25 and 50 mg/kg) were orally administered for the last 4 weeks. "
3.	Liver Cirrhosis (Hepatic Cirrhosis) 06/21/2015 - "Bicyclol significantly attenuates BDL-induced liver fibrosis by reversing fibrogenic gene expression. " 06/21/2015 - "Treatment with bicyclol significantly reduced liver fibrosis and bile duct proliferation after BDL. " 05/01/2010 - "As a result, bicyclol significantly protected against BSA-induced liver fibrosis as evidenced by the reduction of elevated serum HA, PIIIP, and hepatic Hyp in rats, while liver pathological changes were also alleviated. " 05/01/2010 - "Effects of bicyclol on immunological liver fibrosis in rats." 12/17/2004 - "To study the protective effects and related mechanism of bicyclol on liver fibrosis induced by carbon tetrachloride (CCl(4)). "
4.	Fatty Liver 05/01/2015 - "Bicyclol plus lifestyle intervention was effective for chronic hepatitis B combined fatty liver patients with poor biochemical responses." 01/01/2008 - "Bicyclol (150 and 300 mg x kg(-1)) provided significant protection against fatty liver by inhibiting the elevation of hepatic TG and CHO, adjusting abnormal serum lipids, inhibiting the elevation of serum ALT, AST, and ameliorating the severity of pathological changes. " 01/01/2016 - "Therefore, this study was performed to investigate the underlying mechanisms associated with ER stress and apoptosis, by which bicyclol attenuated tetracycline-induced fatty liver in mice. " 01/01/2016 - "Our previous study showed that bicyclol has been proven to protect against tetracycline-induced fatty liver in mice, and ER stress may also be involved in bicyclol's hepatoprotective effect. " 07/10/2009 - "The present study was performed to further investigate the effect of bicyclol on tetracycline-induced fatty liver and related mechanism in mice. "
5.	Inflammation (Inflammations) 01/01/2023 - "Consistent with our previous results, bicyclol significantly inhibited inflammation and oxidative stress pathway related indexes (SAA1, GSTM1 and GSTA1). " 06/24/2022 - "Similar to animal level results, bicyclol could significantly inhibit PA-induced inflammation and prevent NF-κB and MAPK pathways from being activated. " 06/01/2022 - "Bicyclol considerably alleviated hepatic inflammation and apoptosis. " 01/01/2021 - "Not only that, bicyclol markedly attenuated T2DM-NAFLD induced production of inflammation factors (IL-1β and TNF-α). " 06/13/2019 - "Bicyclol can improve liver inflammation and the ALT normalization rate of CHB patients, especially when the treatment course is prolonged. "

Related Drugs and Biologics

1.	Tablets
2.	Lipids
3.	Alanine Transaminase (SGPT)
4.	adefovir dipivoxil (Hepsera)
5.	Hepatitis B e Antigens
6.	Carbon Tetrachloride (Tetrachloromethane)
7.	Biomarkers (Surrogate Marker)
8.	Metformin (Glucophage)
9.	Bilirubin
10.	Potassium Channel Blockers (Blockers, Potassium Channel)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Intraperitoneal Injections
4.	Ligation
5.	Kidney Transplantation