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BILS 45 BS

herpes simplex virus type-1 helicase-primase inhibitor; structure in first source

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - BILS 45 BS: 1
  - Pyridines: 88
    - BILS 45 BS: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - BILS 45 BS: 1

Experts

1.	Browne, Abigail: 1 article (06/2003)
2.	Cordingley, Michael G: 1 article (06/2003)
3.	Dansereau, Nathalie: 1 article (06/2003)
4.	Duan, Jianmin: 1 article (06/2003)
5.	Faucher, Anne-Marie: 1 article (06/2003)
6.	Liard, Francine: 1 article (06/2003)
7.	Liuzzi, Michel: 1 article (06/2003)
8.	Paris, William: 1 article (06/2003)
9.	Simoneau, Bruno: 1 article (06/2003)

Related Diseases

1.

06/01/2003 - "The 50% effective doses of BILS 45 BS were 56.7 and 61 mg/kg/day against dlsptk- and PAA(r)5-induced infections, respectively. "
06/01/2003 - "The oral bioavailability of BILS 45 BS in hairless mice was 49%, with a peak concentration in plasma of 31.5 microM after administration of a single dose of 25 mg/kg. Following cutaneous infection of nude mice, both the HSV-1 dlsptk and PAA(r)5 mutant strains induced significant, reproducible, and persistent cutaneous lesions that lasted for more than 2 weeks. "
06/01/2003 - "This study investigated the oral bioavailability and efficacy of BILS 45 BS, a selective herpes simplex virus (HSV) helicase-primase inhibitor, against acyclovir (ACV)-resistant (ACV(r)) infections mediated by the HSV type 1 (HSV-1) dlsptk and PAA(r)5 mutant strains. "

Related Drugs and Biologics

1.	DNA Primase (Primase)
2.	Acyclovir (Aciclovir)