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SC 514

inhibits IkappaB kinase-2; structure in first source

Also Known As:

SC-514; SC514 cpd

Networked: 8 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - SC 514: 8
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - SC 514: 8

Experts

1.	Chen, Wan-Hsin: 1 article (01/2020)
2.	Chen, Yan-Mei: 1 article (01/2020)
3.	Dumler, J Stephen: 1 article (01/2020)
4.	Gao, Hong-Li: 1 article (01/2020)
5.	Kang, Yu-Ming: 1 article (01/2020)
6.	Li, Hong-Bao: 1 article (01/2020)
7.	Li, Ying: 1 article (01/2020)
8.	Lichay, Marguerite: 1 article (01/2020)
9.	Liu, Kai-Li: 1 article (01/2020)
10.	Park, Jin-Ho: 1 article (01/2020)

Related Diseases

1.	Diabetic Neuropathies (Diabetic Neuropathy) 04/01/2015 - "SC-514 reduces the expression of NF-κB and its downstream inflammatory components which may be involved in the improvement in nerve functions and pain perception in diabetic neuropathy. "
2.	Lung Injury 01/01/2017 - "LBPK95A, SB203580, and SC-514 ameliorated LPS-induced rat lung injury and suppressed LPS-induced downregulation of fractalkine by decreasing phospho-p38 MAPK and p65 NF-κB. "
3.	Osteoporosis 12/15/2013 - "Thus, targeting IKKβ by SC-514 presents as a potential treatment for osteoclast-related disorders such as osteoporosis and cancer-induced bone loss. "
4.	Neoplasms (Cancer) 12/15/2013 - "Thus, targeting IKKβ by SC-514 presents as a potential treatment for osteoclast-related disorders such as osteoporosis and cancer-induced bone loss. "
5.	Neoplasm Metastasis (Metastasis) 03/01/2008 - "SC-514, an inhibitor of IkappaB kinase beta (IKKbeta), blocked the TNF-alpha-induced activation of nuclear factor-kappaB (NF-kappaB) as well as the TNF-alpha-promoted metastasis of murine colon adenocarcinoma cells. "

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	SB 203580
3.	Chemokine CX3CL1
4.	Interleukin-1beta (Interleukin 1 beta)
5.	I-kappa B Kinase
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Prostaglandins E
8.	Phosphotransferases (Kinase)
9.	wedelolactone