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N- ((4- (2- cyanophenyl)- 1- piperazinyl)methyl)- 3- methylbenzamide

a D4 dopamine receptor agonist

Also Known As:

N-(4-2-cyanophenylpiperazin-1-ylmethyl)-3-methylbenzamide maleate; PD 168,077; PD 168077; PD-168,077; PD-168077; PD168,077; PD168077

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Xue-Song: 1 article (01/2020)
2.	Qi, Chun-Lei: 1 article (01/2020)
3.	Wang, Da-Xin: 1 article (01/2020)
4.	Wu, Geng-Ze: 1 article (01/2020)
5.	Xiong, Ting: 1 article (01/2020)
6.	Yang, Yu-Xue: 1 article (01/2020)
7.	Zeng, Chun-Yu: 1 article (01/2020)
8.	Zeng, Jing: 1 article (01/2020)
9.	Cole, Susan: 1 article (06/2011)
10.	Grayson, Ben: 1 article (06/2011)

Related Diseases

1.	Infarction (Infarctions) 01/01/2020 - "DRD4 activated by PD168077 improved cardiac function in the I/R-injured heart as determined by the left ventricular developed pressure (LVDP), +dp/dt, and left ventricular end diastolic pressure (LVEDP), and reduced heart damage evidenced by infarct size, the release of troponin T (TNT) and lactate dehydrogenase (LDH). "
2.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 09/01/2005 - "These present studies evaluated the potential cognitive enhancing properties of A-412997 in rat models of ADHD (5-trial repeated acquisition inhibitory avoidance in Spontaneous Hypertensive Rat pups) and short-term memory (Social Recognition), in comparison with the less selective dopamine D4 receptor agonists PD168077 and CP226269. "
3.	Cognitive Dysfunction 06/01/2011 - "PD168077, a D(4) receptor agonist, reverses object recognition deficits in rats: potential role for D(4) receptor mechanisms in improving cognitive dysfunction in schizophrenia."
4.	Schizophrenia (Dementia Praecox) 06/01/2011 - "PD168077, a D(4) receptor agonist, reverses object recognition deficits in rats: potential role for D(4) receptor mechanisms in improving cognitive dysfunction in schizophrenia."

Related Drugs and Biologics

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2.	Trinitrotoluene (TNT)
3.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
4.	Dopamine D4 Receptors (Dopamine D4 Receptor)
5.	2-(3',4',5',6'-tetrahydro-2'H-(2,4') bipyridinyl-1'-yl)-N-m-tolyl-acetamide