pralnacasan

NSAID, ICE inhibitor & metastasis inhibitor; RN & structure in first source

Also Known As:

N-((2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl)octahydro-9-((1-isoquinolinylcarbonyl)maino)-6,10-dioxo-(1S,9S)-6H-pyridazino(1,2-a)(1,2)diazepine-1-carboxamide

Networked: 8 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - pralnacasan: 8
  - Pyridazines: 11
    - pralnacasan: 8
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - pralnacasan: 8

Experts

1.	Bauer, Christian: 2 articles (07/2007 - 02/2004)
2.	Dauer, Marc: 2 articles (07/2007 - 02/2004)
3.	Eigler, Andreas: 2 articles (07/2007 - 02/2004)
4.	Endres, Stefan: 2 articles (07/2007 - 02/2004)
5.	Lehr, Hans Anton: 2 articles (07/2007 - 02/2004)
6.	Loher, Florian: 2 articles (07/2007 - 02/2004)
7.	Siegmund, Britta: 2 articles (02/2004 - 07/2002)
8.	Hallwachs, Roland: 1 article (07/2007)
9.	Mayer, Christine: 1 article (07/2007)
10.	Schönharting, Martin: 1 article (07/2007)

Related Diseases

1.	Colitis 07/01/2007 - "Pralnacasan prevented DSS-induced colitis in C57BL/6 mice. " 02/01/2004 - "In conclusion, pralnacasan is effective in the prevention of dextran sulfate sodium-induced colitis. " 07/01/2007 - "This study investigates the effects of pralnacasan on cytokine expression in DSS-induced colitis. " 02/01/2004 - "In the present study, we investigated the effect of the specific ICE inhibitor pralnacasan in dextran sulfate sodium-induced murine colitis. " 07/01/2007 - "Previously we demonstrated an ameliorating effect of the interleukin-1beta converting enzyme (ICE) inhibitor pralnacasan on dextran sulfate sodium (DSS)-induced colitis. "
2.	Rheumatoid Arthritis 07/01/2001 - "Pralnacasan, the first orally available, potent and selective ICE inhibitor to enter clinical trials, is currently under investigation in rheumatoid arthritis." 01/01/2007 - "We discuss the use of inflammatory caspase inhibitors, such as VX-740 (Pralnacasan) and VX-765, in clinical studies for rheumatoid arthritis and osteoarthritis. " 05/01/2002 - "However, AG7088 (1) an inhibitor of rhinovirus-3C is in phase II/III clinical trial for the treatment of common cold and VX-740 (2, pralnacasan) an inhibitor of caspase-1 is in phase II clinical trial as an anti-inflammatory agent for rheumatoid arthritis. "
3.	Osteoarthritis 10/01/2003 - "Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis." 01/01/2007 - "We discuss the use of inflammatory caspase inhibitors, such as VX-740 (Pralnacasan) and VX-765, in clinical studies for rheumatoid arthritis and osteoarthritis. "
4.	Knee Osteoarthritis 10/01/2003 - "To study the effect of pralnacasan, the orally bioavailable pro-drug of a potent, non-peptide inhibitor of interleukin-1beta converting enzyme (ICE), RU 36384/VRT-18858, on joint damage in two mouse models of knee osteoarthritis (OA). "
5.	Melanoma (Melanoma, Malignant) 01/01/2003 - "This issue focuses on the following selection of drugs: 81C6; Adefovir dipivoxil, Agalsidase alfa, AGM-1470, albumin interferon alfa, alefacept, alosetron hydrochloride, anakinra, anti-CTLA-4 Mab, aprepitant, aripiprazole, atazanavir; BAY-43-9006, BBR-3438, beta-L-Fd4C, bimatoprost, bortezomib, bosentanBR96-doxorubicin; Caspofungin acetate, ciclesonide, cilengitide, cilomilast, COL-1621, COL-3, CpG-7909, cyclosporine; DCVax-Brain, dexmethylphenidate hydrochloride, dexosome vaccine (melanoma), donepezil hydrochloride, drotrecogin alfa (activated), DTI-015, [99Tc]-DTPA-mannosyldextran, duloxetine hydrochloride; Emivirine, emtricitabine, entecavir, epothilone B, estradiol-MNP, etonogestrel/etonogestrel/ethinylestradiol, etoricoxib; Febuxostat, fondaparinux sodium, fosamprenavir calcium; Gefitinib, GVS-111; Heparinase I, HspE7, human alpha-glucosidase, human insulin; Imatinib mesylate, INGN-241, interferon alfa B/D hybrid, interferon alfa Biphasix, ISIS-14803; Lanicemine hydrochloride, 1311-lipiodol, liposome-encapsulated mitoxantrone, lixivaptan, lumiracoxib, lupus-AHP, LY-466700; Marimastat, MEN-10755, micafungin sodium; Nitronaproxen, NSC-683864 Omalizumab, oral insulin; Palonosetron hydrochloride, peginterferon alfa-2a, pimecrolimus, pralnacasan, pramlintide acetate, pregabalin, pyrazoloacridine; R-165335, ranolazine, risperidone, RPR-109881;, RSD-1235, Satraplatin, seocalcitol, sertindole, SMART anti-interferon gamma antibody, sulfasalazine; T-138067, TAK-013, tegaserod maleate, telithromycin, tenofovir disoproxil fumarate, teriparatide, tiotropium bromide, tipifarnib, TP-38; Valdecoxib, vatalanib succinate, voriconazole; ZD-9331."

Related Drugs and Biologics

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2.	Ice
3.	Caspase 1 (ICE Protease)
4.	Caspase Inhibitors
5.	Cytokines
6.	Prodrugs
7.	Peptides (Polypeptides)
8.	belnacasan
9.	Voriconazole (Vfend)
10.	Dexmethylphenidate Hydrochloride