poly(epsilon- caprolactone)- b- poly(ethylene glycol)

structure in first source

Also Known As:

PCL-b-PEG; Poly(ethylene glycol)-b-poly(epsilon-caprolactone)

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Glycols: 38
    - Ethylene Glycols: 8
      - poly(epsilon-caprolactone)-b-poly(ethylene glycol): 5
Macromolecular Substances: 97
- Polymers: 13051
  - Polyesters: 921
    - poly(epsilon-caprolactone)-b-poly(ethylene glycol): 5
Biomedical and Dental Materials
- Polymers: 13051
  - Polyesters: 921
    - poly(epsilon-caprolactone)-b-poly(ethylene glycol): 5
Technology, Industry, and Agriculture
- Manufactured Materials
  - Biomedical and Dental Materials
    - Polymers: 13051
      - Polyesters: 921
        poly(epsilon-caprolactone)-b-poly(ethylene glycol): 5

Experts

1.	Jones, Steven K: 2 articles (01/2018 - 01/2016)
2.	Merkel, Olivia M: 2 articles (01/2018 - 01/2016)
3.	Douglas, Kirk: 1 article (01/2018)
4.	Shields, Anthony F: 1 article (01/2018)
5.	Lizzio, Vincent: 1 article (01/2016)
6.	De Pauw-Gillet, Marie-Claire: 1 article (01/2014)
7.	Detrembleur, Christophe: 1 article (01/2014)
8.	Duguet, Etienne: 1 article (01/2014)
9.	Grignard, Bruno: 1 article (01/2014)
10.	Jérôme, Christine: 1 article (01/2014)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2018 - "While this is, to the best of our knowledge, the first paper that correlates quantitative tumor accumulation in an orthotopic tumor model with in vivo gene silencing, these data demonstrate that PEI-g-PCL-b-PEG-Fol conjugates are a promising option for gene knockdown in ovarian cancer." 01/11/2016 - "This study demonstrates that PEI-g-PCL-b-PEG-Fol conjugates are a reliable delivery system for siRNA and are able to mediate therapeutic protein knockdown within ovarian cancer cells. " 01/01/2018 - "Using an orthotopic model of ovarian cancer, we studied the delivery of siRNA in nanoparticles of tri-block copolymers consisting of hyperbranched polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) (hyPEI-g-PCL-b-PEG) with and without a folic acid targeting ligand. "
2.	Neoplasms (Cancer) 06/20/2012 - "Therefore, the PEI-g-PCL-b-PEG-Fol merits further investigation under in vivo conditions for targeting FR overexpressing tumors. " 01/01/2018 - "While this is, to the best of our knowledge, the first paper that correlates quantitative tumor accumulation in an orthotopic tumor model with in vivo gene silencing, these data demonstrate that PEI-g-PCL-b-PEG-Fol conjugates are a promising option for gene knockdown in ovarian cancer." 10/10/2011 - "Direct visualization of the micelles within tumor cells by transmission electron microscopy (TEM) confirmed that the 6sPCL-b-PMPC micelles were more efficiently uptaken by tumor cells compared to PCL-b-PEG micelles. "
3.	Melanoma (Melanoma, Malignant) 01/01/2014 - "The cellular uptake of GNR@PCL-b-PEG by melanoma MEL-5 cells was also confirmed, with an averaged uptake of 1250(±110) particles cell(-1) after incubation for 12 h (50 μg mL(-1)). "

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Proteins (Proteins, Gene)
3.	Micelles
4.	Ligands
5.	Folic Acid (Vitamin M)
6.	polyethylenimine- graft- polycaprolactone- block- poly(ethylene glycol)