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(2R,4R)- 4- hydroxy- 2- (2- (2- (2- (3- methoxy)phenyl)ethyl)phenoxy)ethyl- 1- methylpyrrolidine hydrochloride

structure in first source

Also Known As:

(11C)MPM; R-96544; R96544

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - (2R,4R)-4-hydroxy-2-(2-(2-(2-(3-methoxy)phenyl)ethyl)phenoxy)ethyl-1-methylpyrrolidine hydrochloride: 2

Experts

1.	Cabral, A M: 1 article (03/2011)
2.	Futuro Neto, H A: 1 article (03/2011)
3.	Macedo, S M: 1 article (03/2011)
4.	Pires, J G P: 1 article (03/2011)
5.	Silva, N F: 1 article (03/2011)
6.	Asai, Fumitoshi: 1 article (10/2005)
7.	Fujimoto, Koichi: 1 article (10/2005)
8.	Fukushige, Jun-ichiro: 1 article (10/2005)
9.	Ogawa, Taketoshi: 1 article (10/2005)
10.	Sugidachi, Atsuhiro: 1 article (10/2005)

Related Diseases

1.	Chronic Pancreatitis 10/03/2005 - "These results clearly indicate that R-102444 and R-96544 inhibit the progression of acute and chronic pancreatitis and support the contention of possible involvement of 5-HT2A receptors in the progression of experimental pancreatitis." 10/03/2005 - "The effects of R-102444 ((2R, 4R)-4-lauroyloxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine hydrochloride) and its active metabolite R-96544 ((2R, 4R)-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-4-hydroxy-1-methylpyrrolidine hydrochloride), potent and selective 5-hydroxytryptamine 2A (5-HT2A) receptor antagonists, on development of pancreatitis were investigated in experimental models of acute and chronic pancreatitis. " 10/03/2005 - "Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis."
2.	Acute Necrotizing Pancreatitis 10/03/2005 - "Histological analysis showed that R-96544 dose-dependently attenuated pancreatic necrosis, inflammation and vacuolization. "
3.	Pancreatitis 10/03/2005 - "These results clearly indicate that R-102444 and R-96544 inhibit the progression of acute and chronic pancreatitis and support the contention of possible involvement of 5-HT2A receptors in the progression of experimental pancreatitis." 10/03/2005 - "The effects of R-102444 ((2R, 4R)-4-lauroyloxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine hydrochloride) and its active metabolite R-96544 ((2R, 4R)-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-4-hydroxy-1-methylpyrrolidine hydrochloride), potent and selective 5-hydroxytryptamine 2A (5-HT2A) receptor antagonists, on development of pancreatitis were investigated in experimental models of acute and chronic pancreatitis. " 10/03/2005 - "Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis." 10/03/2005 - "In a mouse model of acute pancreatitis induced by a choline-deficient, ethionine (0.5%)-supplemented diet, subcutaneous administration of R-96544 (10-100 mg/kg, bid) reduced serum amylase activity. "
4.	Inflammation (Inflammations) 10/03/2005 - "Histological analysis showed that R-96544 dose-dependently attenuated pancreatic necrosis, inflammation and vacuolization. "
5.	Bradycardia 03/01/2011 - "Ten minutes after the last pre-drug bradycardia, R-96544 (a 5-HT(2A) antagonist; 0.1 µmol/kg), SB-204741 (a 5-HT(2B) antagonist; 0.1 µmol/kg) or vehicle was injected ic. "

Related Drugs and Biologics

1.	5-HT2A Serotonin Receptor (5 HT2A Receptor)
2.	Serotonin (5 Hydroxytryptamine)
3.	Ethionine
4.	Choline (Choline Chloride)
5.	Amylases
6.	R-102444