HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

2-(3-mercaptopropyl)pentanedioic acid

inhibits glutamate carboxypeptidase II; structure in first source

Also Known As:

2-MPPA cpd; GPI 5693

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Glutarates: 35
        2-(3-mercaptopropyl)pentanedioic acid: 2
- Sulfur Compounds: 278
  - Sulfhydryl Compounds: 4168
    - 2-(3-mercaptopropyl)pentanedioic acid: 2

Experts

1.	Bortey, E: 1 article (08/2005)
2.	Burak, E S: 1 article (08/2005)
3.	Cohen, A F: 1 article (08/2005)
4.	Hilt, D C: 1 article (08/2005)
5.	Limsakun, T: 1 article (08/2005)
6.	Slusher, B S: 1 article (08/2005)
7.	Vornov, J: 1 article (08/2005)
8.	Woelfler, M: 1 article (08/2005)
9.	de Kam, M L: 1 article (08/2005)
10.	de Visser, S J: 1 article (08/2005)

Related Diseases

1.

Neuralgia (Stump Neuralgia)

08/01/2005 - "The aim was to assess the central nervous system (CNS) effects, pharmacokinetics and safety of GPI 5693, an inhibitor of a novel CNS-drug target, NAALADase which is being evaluated for the treatment of neuropathic pain. "
05/08/2003 - "The most potent thiol-based inhibitor, 2-(3-mercaptopropyl)pentanedioic acid (IC(50) = 90 nM), was found to be orally bioavailable in rats and exhibited efficacy in an animal model of neuropathic pain following oral administration."

Related Drugs and Biologics

1.	Glutamate Carboxypeptidase II (N-Acetylaspartylglutamate Peptidase)
2.	Sulfhydryl Compounds (Thiols)

Related Therapies and Procedures

1.	Oral Administration